Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Sorbonne Université

Assistance Publique - Hopitaux De Paris (aphp)

Institut Du Cerveau Et De La Moelle Epiniere (icm)

Assistance Publique-hopitaux De Paris

Université Pierre Et Marie Curie (paris 6)

Fondation Icm—institut Du Cerveau Et De La Moelle Epiniere

Université Pierre Et Marie Curie

Centre National De La Recherche Scientifique-cnrs

Institut Du Cerveau Et De La Moelle Epiniere

Pierre Pouget

Thomas Similowski

Jacques Martinerie

Mathieu Raux

Alexis Genin

Jean Lorenceau

Pierre Daye

Mario Chavez

Alexis GÉNIN

A method for generating an indicator or biomarker of colour perception in a mammalian subject, where the method may include submitting the mammalian subject to a multicoloured dynamic stimulus comprising displaying, on a display device. The method may include controlling a change over time of at least one of the two colours of the multicolour pattern when displaying the dynamic multicolour stimulus, to vary the displayed luminance of this colour (usually several times). The method may include acquiring, by using an image acquisition device, an oscillatory response of a pupil of the mammalian subject. The method may include generating, from the acquired response, a signal representative of the power of the pupil's oscillatory response as a function of the change over time of at least one of the two colours when displaying the dynamic multicoloured stimulus.

Determination of chromatic iso-luminance information for controlling a computer process in a personalised manner

Evaluation of the perception of colors by mammals with a view to obtaining a characteristic biomarker of each tested subject takes advantage of the slow pupillary oscillatory response to generate an objective neurological signature of this perception of colors. A method based on pupil frequency tagging is used at a tagging frequency Fadapted to the pupil response speed. A dynamic two-color stimulus is displayed, this stimulus comprising a two-color pattern the colors of which are inverted at the frequency F, one of the colors gradually varying in a range of possible values. From the pupillary response, a signal representative of the oscillation power of the pupil is generated. The minimum of this signal corresponds to the relative iso-luminance of the tested pair of colors.

Biomarker of the colour perception of a mammal subject based on pupil frequency tagging

The invention relates to a method for detecting a physiological state of a patient deviating from a reference physiological state, in which, after having determined, in each of Q frequency bands, R reference matrices PRwith qe[1 . . . Q] and r&#x3f5;[1 . . . R] which correspond to the reference physiological state, the following steps are repeated in a loop: carrying out measurements, in M time segments, of an electroencephalographic signal; filtering and centering the measurements in Q frequency bands to obtain and determine M&#xd7;Q scaled matrices of spatial covariance; for each time segment m, calculating a deviation from the reference physiological state, and comparing each of the deviations from the reference physiological state to a predefined threshold. The invention also relates to a monitoring device applying said method.

Method for characterizing the physiological state of a patient from the analysis of the cerebral electrical activity of said patient, and monitoring device applying said method

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Paris, France

Pierre Pouget