Sanofi-aventis

Sanofi-synthelabo

Elf Sanofi

Elf Sanofi, a French Corp.

Pierre Perreaut

Bernard Ferrari

Claude Muneaux

Yvette Muneaux

Jean Gougat

Pierre Casellas

Samir Jegham

Bernard Bourrie

Claudine Planchenault

Claude Bernhart

Jean-Louis Assens

Lionel Sarran

Jean-Robert Labrosse

Joelle Arnaud

Florence Durand

Frederique Haudricourt

Derivatives of pyrido[2,3-d]pyrimidine are provided having formula (I) with Ar, Arand Ras defined herein, which are useful for treating cell proliferative conditions, and to the preparation thereof, and to the therapeutic application of the same.

Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same

The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof

The disclosure relates to pyrido[2,3-d]pyrimidone compounds, to the preparation thereof and to the therapeutic use thereof, wherein said compounds are of general formula (I): in the form of a base or of an addition salt with an acid which is pharmaceutically acceptable, in the form of hydrates or of solvates, and also in the form of enantiomers, diastereoisomers and a mixture thereof. The disclosure also relates to processes for preparing said compounds, to pharmaceutical compositions containing a compound of general formula (I), and to the therapeutic use of said compounds and compositions.

Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof

The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same.

The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the Breceptors; they may be used for the preparation of medicinal products intended for treating or preventing inflammation pathologies and persistent or chronic inflammatory diseases.

Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same

N-(arylsulphonyl) amino acid derivatives

N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them

The invention relates to compounds of formula

N-(arylsulfonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them

The invention relates compounds of formula ##STR1## in which R.sub.1 to R.sub.9, R.sub.16 and R.sub.17 are as defined in claim 1. These compounds are pharmacologically active.

N-(arylsulphonyl)amino acid derivatives, process for their preparation

N-(arylsulphonyl)amino acid derivatives having bradykinin receptor

The present invention relates to N-substituted heterocyclic derivatives of formula: ##STR1## processes for their preparation, and pharmaceutical compositions which contain them. The compounds according to the invention are non-peptide compounds which oppose the action of angiotensin II. The compounds according to the invention are thus useful in the treatment of cardiovascular disorders such as hypertension and heart failure.

N-substituted heterocyclic derivatives useful in the treatment of

This invention relates to compounds of formula ##STR1## in which: R.sub.1 and R.sub.2 are similar or different and are each independently hydrogen or a group selected from CO.sub.2 N.dbd.C(NH.sub.2).sub.2, CONHNHCONH.sub.2, CONHNHCSNH.sub.2, C(OC.sub.2 H.sub.5).dbd.NCO.sub.2 CH.sub.3, COCH.sub.2 CO.sub.2 H.sub.5, N(OH)-CONHCOOC.sub.2 NCO.sub.2 CH.sub.3, COCH.sub.2 CO.sub.2 H.sub.5, N(OH)-CONHCOOC.sub.2 H.sub.5, C(OC.sub.2 H.sub.5).dbd.NH or a nitrogen heterocycle; with the proviso that at least one of the substituents R.sub.1 or R.sub.2 is other than hydrogen;

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Saint-Clement-de-Riviere, France

Pierre Perreaut