Sanofi

Ucb S.a.

Chemcom S.a.

Givaudan S.a.

Elf Sanofi

Pierre P Chatelain

Jean Gubin

Henri Inion

Jean Lucchetti

Dino Nisato

Marcel Descamps

Jean-Marie Mahaux

Jean-Noel Vallat

Xiong Cai

Timothy A Lewis

Sajjat Hussoin

Gurmit Grewal

Anna Toy-Palmer

Ralph Scannell

Alex Veithen

James Ellis

Marie-Agnes Lassoie

Edmond Differding

Gilbert Rosseels

Michelle Young

Gerard R Le Fur

Jean-Marc Herbert

Markus Gautschi

Yannick Quesnel

Thierry Granier

Michel Goldman

Charles Stanley Sell

Anne Mignot

Mark Taubman

Edmund Differding

Allan S Manning

The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R, R, R, R, R, R, Rand X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds. 

Compounds reducing malodour perception and the use thereof

The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.

Method for counteracting the perception of sweat malodour by decreasing the function of carboxylic acid-binding olfactory receptors

Methods of identifying modulators of olfactory receptors involved in the perception of sweat carboxylic acids

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

Compounds and methods for treatment of asthma, allergy and inflammatory disorders

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

A CD40 signal blocking agent comprising, as an active ingredient, s-triazolo&lsqb;1,5-a&rsqb;pyrimidine derivative represented by the following formula (1) or a pharmaceutically acceptable salt thereof, is disclosed

CD40 signal blocking agent

The invention relates to use of at least one indole derivative of general formula: ##STR1## or of one of the pharmaceutically acceptable salts thereof, in which: Am is selected from radical (a) and (b) defined as follows: ##STR2## R is a C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl radical R.sub.1 represents hydrogen or a C.sub.1 -C.sub.4 alkyl radical R.sub.2 and R.sub.3, which may be identical or different, represent hydrogen, the methyl or ethyl radical or a halogen R.sub.4, R.sub.5 and R.sub.6, which may be identical or different, represent hydrogen, a C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy radical or a halogen R.sub.7 represents hydrogen or a halogen R.sub.8 represents hydrogen or a C.sub.1 -C.sub.4 alkyl radical R.sub.9 represents hydrogen or, when R.sub.8 and R.sub.9 are taken together, form the methylene radical m represents 1 or 2 n represents 2, 3 or 4 for preventing or treating diseases involving a proliferation of smooth muscle cells.

Benzenesulphonylindole derivatives for the preparation of medicines

Cycloaminoalkoxyphenyl derivatives useful for the treatment of certain pathological syndromes of the cardiovascular system and ocular diseases of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group,

Cycloaminoalkoxyphenyl derivatives, a process for their preparation as

An aminoalkoxyphenyl derivative of general formula:

Aminoalkoxyphenyl derivatives, process for their preparation and

The present invention relates to the use of a 1-(2-naphtylethyl) -4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine of formula (I): ##STR1## or one of its pharmaceutically acceptable salts, as a cardioprotector.

Tetrahydropyridine derivatives for the preparation of cardioprotective

Cycloaminoalkoxyphenyl derivatives useful for the treatment of certain pathological syndromes of the cardiovascular system and ocular diseases of formula: in which:

The subject of the invention is benzofuran, benzothiophene, indole or indolizine compounds of general formula: ##STR1## in which: Het represents one of the groups: ##STR2## in which T,T' and T'represent particularly a group: ##STR3## R and R.sub.a, identical or different, represent X represent --O-- or --S--

Alkylaminoalkyl derivatives of benzofuran, benzothiophene, indole and

The present invention relates to aminoalkoxyphenyl compounds of formula: ##STR1## in which: B is selected from --S--, --SO-- and --SO.sub.2 --,

Aminoalkoxyphenyl derivatives, process of preparation and compositions

Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group,

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Bruxelles, Belgium

Pierre P Chatelain