Recherches Pharmaceutiques Et Scientifiques

Metabio Joullie

Pierre Muller

Christian J Warolin

Bernard Gaudilliere

Maurice Joullie

Gabriel Maillard

Lucien Lakah

Paul M Fabiani

Roger Zaoui

Francis E Rose

There are provided compounds of the general formula ##STR1## in which Ar represents a phenyl group which is unsubstituted or substituted by a halogen atom or a lower alkyl group, or represents a thienyl group, R.sub.1 represents a hydrogen or halogen atom or, when the Ar--CO-- grouping is in the meta-position with respect to the nitrogen atom, a lower alkyl group, R.sub.2 represents a hydrogen atom, or a lower alkyl or an acyl group, and R.sub.3 represents a hydrogen atom, a lower alkyl or a phenyl group and a physiologically acceptable salt thereof. The compounds of the general formula I and their salts have therapeutic utility, especially as analgesics.

Therapeutically useful N-phenylaniline derivatives

Compounds of the formula ##STR1## (in which n is equal to 0 or represents a whole number from 1 to 10 and m represents the number 1 or 2) and their pharmacologically acceptable salts are prepared and have therapeutic, in particular hypolipemic, activity.

Therapeutically useful cysteinol and homocysteinol derivatives

S-substituted cysteines, alkyl esters of S-substituted cysteines and S-substituted glutathiones in which the substituent on the S atom is allyl, geranyl, cinnamyl, benzylidene-3-butyl, 1-(para-chlorophenyl)ethyl and (pyridyl-3)methyl but excluding S-allyl cysteine bring about a reduction in atheromatic deposits in the aorta of test animals as well as a reduction in hypercholesterolemia and are of low toxicity. They may be used by the conventional routes for the treatment of human atheromatic conditions and disorders of the lipid metabolism.

Cysteine derivatives

Growing community of inventors

Paris, France

Pierre Muller