Sanofi

Sanofi-aventis

Dropic - Societe Civile De Gestion De Droits De Propriete Industrielle

Sanofi-synthelabo

Sanofi Sa

Elf Sanofi

Choay, S.a.

Pierre M Roger

Jean-Paul Fournier

Patrick Choay

Danielle Gully

Gihad Dargazanli

Michel Jacques Geslin

Camille G Wermuth

Benoit Marabout

Genevieve Estenne-Bouhtou

Pascale Magat

Mireille Sevrin

Evelyne Fontaine

Dominique Olliero

Claude Monneret

Antoine Pradines

Benoît Marabout

Gilles V Courtemanche

Alain Martin

Geneviève Estenne-Bouhtou

Claudie Suzanne Gautier

Jean Choay

Jean-Pierre Maffrand

Gerard Valette

Camille Georges Wermuth

Gilles Courtemanche

Florence Medaisko

Corinne Veronique

Daniele Anne Gully

Claudie Gautier

Daniel A Gully

Rolande Leroy

The invention relates to use of compositions in therapeutics containing a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein.

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Substituted 4-phenyl-2-aminothiazole derivatives, processes for preparing the same, and the use thereof as corticotrophin releasing factor (CRF) antagonists.

Aminothiazole derivatives and their use as CRF receptor ligands

This invention discloses and claims a compound of general formula (I) in which Rrepresents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, Rrepresents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.

N-[phenyl(piperidin-2-yl)methyl]benzamide derivatives, preparation thereof, and use thereof in therapy

The invention relates to compositions comprising a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.

The present invention discloses and claims a compound of general formula (I) wherein A, X and Rare as described herein. Also disclosed and claimed is application of this compound in a variety of therapeutic applications.

N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application in therapy

The invention relates to a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.

Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics

N-[phenyl (piperidin-2-yl) methyl]benzamide derivatives, preparation thereof, and use thereof in therapy

The present invention relates to novel branched substituted amino derivatives of 3-amino-1-phenyl-1H-&lsqb;1,2,4&rsqb;triazole, processes for their preparation and pharmaceutical compositions comprising them.

Branched substituted amino derivatives of 3-amino-1-phenyl-1h-&lsqb;1,2,4&rsqb;triazol, methods for producing them and pharmaceutical compositions containing them

Substituted 4-phenyl-2-aminothiazole derivatives, processes for preparing the same, and the use thereof as corticotropin releasing factor (CRF) antagonists.

Aminothiazole derivatives, method of preparation and pharmaceutical compositions containing same

Substituted 4-phenylaminothiazoles, their process of preparation and the

The invention concerns compounds of the formula I: ##STR1## in which R.sub.1 to R.sub.5 are as defined in claim 1. These compounds find their application in the treatment of pathologies involving CRF.

Branched-amino-substituted thiazoles, processes for their preparation

The invention relates to the derivatives of formula I: ##STR1## in which R.sub.1 represents a phenyl or naphthyl radical (optionally substituted), R.sub.2 represents a hydrogen or halogen atom or an alkyl, hydroxymethyl or formyl radical, R.sub.3 represents an alkyl, cycloalkyl, alkenyl, cycloalkylalkyl or phenyl radical, R.sub.4 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl radical, R.sub.5 represents an alkyl, cycloalkyl, cycloalkylalkyl or alkenyl radical or a radical of formula B: ##STR2## (p=0, 1, 2 or 3), R.sub.6 represents a phenyl, pyridyl, imidazolyl, pyrrolyl, thienyl or furyl radical, optionally substituted, or a cycloalkyl radical,

Branched alkylamino derivatives of thiazole, processes for preparing

The invention relates to nitrosourea derivatives, a process for their preparation and pharmaceutical compositions containing them. The nitrosourea derivatives of the invention correspond to the following formula (I): ##STR1## in which: R can represent a hydrogen atom or an alkyl group from 1 to 30 carbon atoms, X represents a hydroxy group or an -NR.sub.1 R.sub.2 group, Y represents a hydrogen atom, a hydroxy group or an -NR'.sub.1 R'.sub.2 group, where R.sub.1 and/or R'.sub.1 each represent a hydrogen atom or a ##STR2## group, Hal being a halogen, and R.sub.2 and/or R'.sub.2 can each represent a hydrogen atom or an alkyl group comprising from 1 to 6 carbon atoms, R' and R' can represent hydrogen or OH, provided that at least X represents ##STR3## with R.sub.1 representing ##STR4## or Y represents ##STR5## with R'.sub.1 representing ##STR6## and provided that either R' represents hydrogen or R' represents hydrogen, and R' and R' cannot be simultaneously hydrogen atoms. These compounds present an antitumor activity.

Process for preparing nitrosourea derivatives

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Montigny le Bretonneux, France

Pierre M Roger