Universita′ Degli Studi Di Milano

Ieo - Istituto Europeo Di Oncologia S.r.l.

I.r.c.c.s. “Casa Sollievo Della Sofferenza”

Istituto Europeo Di Oncologia S.r.l.

Fondazione Di Religione E Di Culto "Casa Sollievo Della Sofferenza" - Opera Di San Pio Da Pietrelcina

Pierre-Luc Germain

Giuseppe D'Agostino

Giuseppe Merla

Sina Atashpazgargari

Giuseppe Testa

Matteo Zanella

Antonio Adamo

Giuseppe D'AGOSTINO

The present invention relates to iPSC produced from fibroblast obtained from a subject affected by a neurodevelopmental disorder entailing intellectual disability (ID) and/or a disorder belonging to the Autism Spectrum Disorder (ASD) and/or Schizophrenia (SZ) and uses thereof. The present invention also relates to a cortical neural progenitor cell or a terminally differentiated cortical glutamatergic or gabaergic neuronal cell or a neural crest stem cell line, a mesenchymal stem cell line produced from the iPSC or iPSC line. The invention also relates to method for identifying a compound for the treatment and/or prevention of a neurodevelopmental disorder entailing intellectual disability (ID) and/or a disorder belonging to the Autism Spectrum Disorder (ASD) and/or Schizophrenia (SZ) and to a LSD1 inhibitor or a HDAC2 inhibitor for use in the treatment of such disorders.

Reprogramming-based models of neurodevelopmental disorders and uses thereof

Growing community of inventors

Milan, Italy

Pierre-Luc Germain