Centre National De La Recherche Scientifique

Aventis Pharma S.a.

Institut National De La Sante Et De La Recherche Medicale

Université De Bretagne Occidentale

Universite Pierre Et Marie Curie—paris 6 (Upmc)

Ecole Nationale Superieure De Chime De Rennes

Jean-Marie Lehn

Pierre Lehn

Jean-Pierre Vigneron

Thierry Benvegnu

Jean-Luc Decout

Daniel Plusquellec

Bruno Pitard

Claude Ferec

Frederic Becq

Tristan Montier

Pascal Delepine

Isabelle Callebaut

Romain Haudecoeur

Antoine Fortune

Clement Boinot

Julien Alliot

Brice Hoffman

Gildas Rethore

Jean-Paul Mornon

Benjamin Boucherle

Mickaelle Scahet

Mickaelle Sachet

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable enantiomers, salts, solvates or prodrugs thereof. The invention further relates to the use of the compounds of Formula (I) for the treatment of cystic fibrosis. The invention also relates to a process for manufacturing compounds of Formula (I). 

Compounds for treating cystic fibrosis

The invention relates to a compound of general formula (I): where X=0 or 1, Z=O, S or CH, Rand Rindependently=OH or OY, where Y=a protecting group, OR, where R=a monosaccharide or disaccharide group, A-CH&#x2014;N(CH), X', where X=halogen, A=an amide (NHC(O)) or ester (OC(C)) bond, OPO(OM), where M=an alkyli or alkyli earth metal, OP(O)O&#x2014;O(CH)&#x2014;N(CH), A-(PEG-A)-R, where n=0 or 1, PEG=a polyethyleneglycol of molecular weight X, where Xbeing less than or equal to 5,000 daltons, Aand Aindependently=a ether (O), ester (OC(O)), amide (NHC(O)), urea (NHC(O)NH), thiourea (NHC(S)NH), or thioether (S) bond R=a directing agent. 

Analogue compounds of archaebacterial membrane lipids and liposomal compounds integrating such compounds

Transfecting compounds which include an aminoglycoside linked to a lipid via a spacer, and their polyguanidylated derivatives are provided. These compounds are useful for the in vitro, ex vivo, or in vivo transfection of nucleic acids into various cell types.

Lipid derivatives of aminoglycosides

Novel amidinium derivatives of formula (I), wherein R1 is a cholesterol derivative or an alkylamino-NR&prime;R&Prime; grouping, and each of R2 and R3 is independently a hydrogen atom or a grouping of formula (II), wherein each of R4 and R5 is independently a hydrogen atom or a grouping of formula (III), are disclosed. The corresponding pharmaceutical compositions, which are particularly useful in gene therapy for transferring therapeutic genes into cells, are also disclosed.

Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof

Compounds related to the amidinium family, pharmaceutical compositions

Growing community of inventors

Brest, France

Pierre Lehn