Agence Nationale De Valorisation De La Recherche (anvar)

Choay, S.a.

Agence Nationale De Valorisation De La Recherche

Vacsyn S.a.

Harvard College

Institut National De La Sante Et De La Recherche Medicale

Sandoz Gmbh

Agence Nationale De Valorisation

Pierre Lefrancier

Louis A Chedid

Jean Choay

Edgar Lederer

Francoise Marguerite Audibert

Monique Parant

Pierre G Sinay

Jean-Francois Petit

Arlette Adam

Edgar Sache

Rita Ciorbaru

Claude Merser

Fabrielle Ellouz

Dominique Juy

Michel Level

Georges Bahr

Michael Sela

Peter Stutz

Jean-Francois Bach

Meir Rigbi

Claude Carelli

Jean Hamburger

John R Pappenheimer

James M Krueger

Mireille Dardenne

Jean-Marie Pleau

Genevieve Auger

Manfred L Karnovsky

Yves Legrand

Jean Martinez

Didier Blanot

Francine Parant

Jacques Caen

Jean-Marie Bernard

Evangheios Bricas

Bernard Amor

Yakir Klausner

Arlette Adam, Nee Chosson

Nigel Phillips

Marcel Derrien

Peter Dukor

Pharmaceutical compositions containing Muramyl dipeptide derivatives and conjugates or Muramyl dipeptide derivatives and conjugates combined with nucleoside derivatives which induce hematopoietic stem cell stimulation and mobilization into the circulating blood system. Methods to induce hematopoietic stem stimulation and mobilization, as well as methods to decrease myelotoxic effects using these pharmaceutical compositions.

MDP derivatives and conjugates having haematipoietic function stimulating activity, and compositions containing same

Compositions and methods for the use of such compositions in human

The 3-O-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn-glycerol derivative of formula I ##STR1## wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration, possesses interesting pharmacological, in particular immunomodulating properties. It is particularly useful as an immunomodulant, as an adjuvant in vaccines and as a suppressing agent for IgE formation in e.g. type I allergies and atopical dermatitises. It is obtained by deprotection of a corresponding compound having one or more hydroxy group(s) in protected form.

Muramyl dipeptide derivatives

The invention relates to muramyleptide derivatives resulting essentially from the conjugation or the coupling, as the case may require, through an arm, between a muramylpeptide and a group containing two atoms contiguous with one another to each of which is attached a lipophile chain comprising from 8 to 100 carbon atoms, preferably from 14 to 24 carbon atoms. The derivatives according to the invention are endowed with remarkable stimulating properties with respect to the activation of macrophages, of which they amplify the tumoricidal properties.

Lipophile derivatives of muramylpeptides having properties of activating

Biological compositions which induce sleep of the slow-wave type which comprise biological carriers and sleep-inducing muramyl peptides such as acetylmuramyl-L-alanyl-D-isoglutamine and derivatives thereof and methods of using such compositions.

Somnogenic compositions and method of use

The compounds have the structure 2-(2-amino or alkyl-amido-2-desoxy-3-O-D-glucopyranosyl)-alkanyl-dipeptide, possibly substituted on the saccharide residue the amino acid residue at the end of the peptide chain being a D-glutamyl residue whose .alpha.-carboxy function is esterified and .gamma.-carboxyl function amidated. The compounds are valuable as immunological medicaments.

Novel compounds of the muramyl peptide

The present invention relates to novel peptide compounds, of which the chemical structure is related to that of the polypeptide hormone having a thymic activity, isolated from the blood serum of pig, and the application of these novel compounds for therapeutic purposes. This invention also relates to intermediates useful in preparing the active compounds of the invention.

Metal polypeptides

The invention relates to an immunogenic principle containing a specific antigen determinant of a predetermined native antigen. This immunogenic principle is constituted by a conjugate between a hapten bearing said antigenic site and a muramyl-peptide, essentially in the absence of supporting macromolecules, this conjugate having an immunogenic effect not only against itself, but also with respect to the native antigen carrying said antigenic site.

Conjugates of haptenes and muramyl-peptides, endowed with immunogenic

Oligopeptides with specific inhibiting properties of collagen induced

The novel products are water-soluble oligomers, free of N-acetyl-glucosamine units, and of which the monomer elements include a group derived from muramic acid on which is fixed a chain of the peptide type including at least two aminoacyl residues, the first being selected from among: L-alanyl, L-arginyl, L-asparagyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-methionyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tryptophanyl, L-valyl, and the second aminoacyl is D-glutamyl or D-isoglutaminyl. They are useful for their immunoregulator properties and for the preparation of pharmaceutical compositions.

Oligomers of compounds of the muramyl-peptide type and medicaments

A polymer of peptidic type formed by a chain formed from aminoacyl residues preferably derived of at least one of the amino-acid residues selected from the class consisting of .alpha.,.gamma.-diaminobutyric acid, ornithine, lysine, homo-lysine, of which the lateral amino functions portionally carry peptide branches of which the aminoacyl residues are preferably derived of those selected from the class consisting of alanine, glycine, .alpha.-aminobutyric acid, valine, leucine and proline, the above-said peptide polymer having an average molecular weight comprised between about 50,000 and 250,000, and to which are bound covalently, muramyl-peptide units of which the two first aminoacid residues bound to the muramyl group are stereoisomers of the D series, the second aminoacid residue having the structure of the glutamic acid. This product is useful as anti-infectious agent.

Muramyl-peptides fixed to peptide-polymers and pharmaceutical

The invention relates to new compounds useful notably as regulator of immune responses and which are derivatives of muramyl peptides substituted at the end of the peptide chain by a group containing at least four carbon atoms.

Muramyl peptide derivatives and pharmaceutical compositions

Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens, comprising an acyl-muramic acid group, wherein acyl means acetyl or glycolyl, and a short peptide chain linked to said acyl-muramic acid group, the first and second amino acids of said peptide chain being preferentially alanine and glutamic acid respectively.

Water soluble agents effective as immunological adjuvants for

The invention relates to new compounds associating peptidyl or aminoacyl residues to lipophilic groups and pharmaceutical compositions containing said new compounds. The compounds according to the invention have the general formula: ##STR1## A preferred compound is:

Compounds associating peptidyl of aminoacyl residues to lipophilic

The invention relates to water-soluble biologically active agents, having anti-infectious and adjuvant properties. They have the general formula ##STR1## wherein X, Y, Z, R.sub.2, R.sub.4 and R.sub.6 have the meanings defined in claim 1. The invention also relates to pharmaceutical compositions containing these compounds in association with a pharmaceutical vehicle, particularly an oil-free one.

Biologically active compositions and methods of use

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Bures sur Yvette, France

Pierre Lefrancier