Bio-mega/boehringer Ingelheim Research Inc.

Pierre Lavall Ee

Pierre Louis Beaulieu

Christiane Yoakim

Bruno Simoneau

Paul C Anderson

Francedillaois Soucy

Disclosed herein are compounds of formula 1 ##STR1## wherein X is a terminal group, for example, an aryloxycarbonyl, an alkanoyl or an optionally mono- or disubstituted carbamoyl; B is absent or an amino acid residue, for example, Val or Ash; R.sup.1 is hydrogen or a ring substituent, for example, fluoro or methyl; R.sup.2 is alkyl; and Y is a ring substituent, for example, phenoxy, 2-pyridinylmethoxy, phenylthio or 2-pyridinylthio. The compounds inhibit the activity of human immunodeficiency virus (HIV) protease and interfere with HIV induced cytopathogenic effects in human cells. These properties render the compounds useful for combating HIV infections.

Substituted pipecolinic acid derivatives as HIV protease inhibitors

Disclosed herein are compounds of the formula:

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Rosem ere, Canada

Pierre Lavall Ee