Compagnie Laitiere Europeenne

Piere Jouan Biotechnologies S.a.

Pierre Jouan Biotechnologies S.a.

Pierre Jouan

Michel Bourtourault

Jean-Louis Joseph Maubois

Jacques Fauquant

Jérôme Souppe

Takashi Mikogami

Jacques Fauguant

Jean-Louis Maubois

The invention concerns a method for obtaining a highly enriched TGF-beta protein fraction in activated form, from a liquid solution rich in proteins said to be soluble in the aqueous phase of milk and/or of whey, said method comprising the following steps; a) adjusting soluble proteins purified at a concentration between 5 and 30 g/liter of solution; b) precipitating part of the whey proteins by acidic treatment of the solution thus obtained to a pH ranging between 4 and 5.5 and at a temperature ranging between 55&#xb0; C. and 68&#xb0; C.; c) carrying out a microfiltration of the treated solution by diafiltration, so as to obtain respectively a microfiltration retentate and a microfiltrate; d) recuperating the microfiltration retentate containing the protein fraction highly enriched in TGF-beta; e) drying the microfiltration retentate which has been subjected to diafiltration to obtain a powder highly enriched in TGF-beta.

Method for obtaining a TGF-beta enriched protein fraction in activated form, protein fraction and therapeutic applications

The invention concerns TGF-&#x3b2;-enriched milk protein fractions, a method for preparing same and use thereof for preparing a medicine and/or a food composition for preventing and/or treating chronic inflammatory diseases, and in particular psoriasis.

Milk protein fractions and use thereof for preventing or treating chronic inflammatory diseases

Growing community of inventors

Cesson Sevigne, France

Pierre Jouan