Janssen Sciences Ireland Uc

Janssen Sciences Ireland Unlimited Company

Katholieke Universiteit Leuven

Janssen Pharmaceuticals, Inc.

Medivir Ab

Janssen R&d Ireland

Aligos Therapeutics, Inc.

Tibotec Pharmaceuticals Ltd.

Janssen Products, LP

Janssen Pharmaceutica Nv

Tibotec Bvba

Medivar Ab

Janssen Vaccines & Prevention B.v.

Janssen Biopharma, Inc.

Elanco Animal Health Ireland Limited

Pierre Jean-Marie Bernard Raboisson

Tim Hugo Maria Jonckers

David Craig McGowan

Abdellah Tahri

Koen Vandyck

Sandrine Marie Helene Vendeville

Lili Hu

Stefaan Julien Last

Jean-François Bonfanti

Bart Rudolf Romanie Kesteleyn

Kenneth Simmen

Dorothée Alice Marie-Eve Bardiot

Dominique Louis Nestor Ghislain Surleraux

Arnaud Didier M Marchand

Herman Augustinus De Kock

Werner Embrechts

Ludwig Paul Cooymans

Karl Magnus Nilsson

Serge Maria Aloysius Pieters

Samuël Dominique Demin

Bengt Bertil Samuelsson

Jérôme Émile Georges Guillemont

Wim Gaston Verschueren

Geerwin Yvonne Paul Haché

Jérôme Michel Claude Fortin

Åsa Annica Kristina Rosenquist

Jerome Deval

Tse-I Lin

Ioannis Nicolaos Houpis

Antitsa Dimitrova Stoycheva

Frédéric Marc Maurice Doublet

Geert Rombouts

Oliver Lenz

Antoine Benjamin Michaut

Leonid Beigelman

David Francis Alain Lançois

Philippe Muller

Dirk André Emmy Roymans

Sandrine Vendeville

Guillaume Jean Maurice Mercey

Per-Ola Mikael Johansson

Wim Van De Vreken

Asa Annica Kristina Rosenquist

Vladimir Kirillovich Ivanov

Mikael Pelcman

Werner Constant Johan Embrechts

Erwin Coesemans

Eric Pierre Alexandre Arnoult

David Craig Mc Gowan

Yannick Debing

Steven Maurice Paula Van Hoof

Anna Karin Gertrud Linnea Belfrage

Samuel Dominique Demin

Jaromir Vlach

Christophe Francis Robert Nestor Buyck

Anil Koul

Piet Tom Bert Paul Wigerinck

Tongfei Wu

Wendy Mia Albert Balemans

Vadim Bichko

Delphine Yvonne Raymonde Lardeau

Dmitry Antonov

Boris Rogovoy

Peter Rigaux

Anna Karin Gertrud Linea Belfrage

Björn Olof Classon

Cheng Liu

Francois Gonzalvez

Annick Ann Peeters

Pia Kahnberg

Hans Kristian Wallberg

Benoît Christian Albert Ghislain De Boeck

Arnaud Didier Marie Marchand

Sandro Boland

Lourdes Salvador Odén

Werner Constant J Embrechts

Abdellah Tahari

Katie Ingrid Eduard Amssoms

Mourad Daoubi Khamlichi

Karin Charlotta Lindquist

Horst Jürgen Wähling

Sarvajit Chakravarty

Magali Madeleine Simone Motte

Robert Than Hendricks

Bertil Samuelsson

Zhao-Kui Wan

Vladimir Serebryany

Haibing Guo

Jerome Emile Georges Guillemont

Barry Patrick Hart

Horst Wahling

Jean-Francois Bonfanti

Boerries Brandenburg

Jerome Michel Claude Fortin

Anna Winqvist

Jaroslaw Juraszek

Wim Bert Griet Schepens

Frederic Marc Maurice Doublet

Sandrine Céline Grosse

Maria Van Dongen

The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Methods and compositions for targeting PD-L1

Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Bicyclic compounds

Anti-viral compounds

The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.

Antibacterial compounds

Disclosed herein are compounds of Formula I: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Bicyclic pyridazinones and methods of use thereof

Substituted imidazo[1,5-a]pyrazines for the treatment of hepatitis B

Disclosed herein are compounds of Formula I': or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a patient with one or more of the above compounds.

Modulators of THR-&#x3b2; and methods of use thereof

The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Tricyclic compounds

Disclosed herein are compounds of Formula I': or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Oxindoles and methods of use thereof

The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Substituted indoline derivatives as dengue viral replication inhibitors

Disclosed herein are compounds of Formula I&#x2033;: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

2-pyridones and methods of use thereof

Growing community of inventors

Rosieres, Belgium

Pierre Jean-Marie Bernard Raboisson