Science Union Et Cie, Societe Francaise De Recherche Medicale

Adir Et Compagnie

Science Union Et Cie

Adir, S.a.r.l.

Science Union Et Cie, Societe Francaise De Recherche Medical

Pierre Hugon

Laszlo Beregi

Jacques Duhault

Michelle Boulanger

Jean-Claude Poignant

Michel Wierzbicki

Xavier B Pascaud

Francoise Lacour

Charles E Malen

Jacques DuHault

Jacques Bure

Francoise Degrand

The compounds are ethanolamine benzoate compounds useful for the treatment of syndrome X, and of hypertension in patients who are insulin resistant or have one or more metabolic anomalies. A compound disclosed is S-1-(m-trifluoromethylphenyl)-2-{.beta.-{4-[2-(N-(3,3-diphenylpropionyl)am ino)ethyl] benzoyloxy}ethylamino} propane.

Ethanolamine benzoate compounds

New ethanolamine benzoate compounds which can be used as medicaments and correspond to the formula: ##STR1## wherein R is as defined in the description, in the form of racemic compounds and enantiomers. These new compounds and their physiologically tolerable salts can be used therapeutically for treatment of insulin-resistance states.

The compounds 2-trifluoromethyl-7-substituted-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes are disclosed and disclosed to be useful in the treatment of metabolic illnesses such as diabetes, obesity, and their complications. A perferred compound is 2-trifluoromethyl-7-amino-6,7,8,9-tetrahydro-[5H-benzocycloheptane.

2-trifluoromethyl-7-substitute-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes

Triazole compounds of the formula: ##STR1## in which: X and X', which are the same or different, each represents hydrogen, halogen, trifluoromethyl, C.sub.1 -.sub.5 alkyl, or C.sub.1 -.sub.5 alkoxy, or

N-(N'-phenylpiperazine)-alkyl triazole compounds having anxiolytic and

New sulfonylurea compounds of the formula: ##STR1## in which n is 1 or 2,

Sulfonylurea compounds and their use in treating diabetes

1-methyl-4-piperidinol esters of the formula: ##STR1## in which R is 7-chloro-4-quinolyl, 7-trifluoromethyl-4-quinolyl or 8-trifluoromethyl-4-quinolyl. These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of inflammatory processes and painful syndroms.

1-Methyl-4-piperidinol esters of 4-quinolinylamino benzoates and

Pyrrolidone derivatives of the formula: ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl, And

Phenoxy phenyl pyrrolidine compounds, compositions and methods of use

Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2

N-substituted-2-aminomethyl-3-azabicyclo(3,3,0)octane compounds

Phenoxy compounds of the formula: ##STR1## wherein R and R', which are the same or different, are hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, lower alkoxy-carbonyl or dimethylsulfamoyl. These compounds are used as medicines especially in the treatment of glucid -- and lipid -- metabolism disorders.

N-Phenoxyphenyl-piperazines

Disubstituted azabicycloalkanes

Alkanolamine derivatives and their optical isomers of the formula: ##STR1## wherein: N IS 2 OR 3, AND

Alkanolamine derivatives

Disubstituted azabicycloalkanes of the formula ##SPC1## Wherein:

N-substituted glycinates of the formula: ##EQU1## optical isomers and acid addition salts thereof, wherein R is cyclopentyl, cyclohexyl, benzyl, halobenzyl, lower alkylbenzyl, lower alkoxybenzyl, methylenedioxybenzyl or trifluoromethylbenzyl. These compounds are used as medicines especially in the treatment of obesity or other metabolic diseases needing weight reduction and regulation.

Growing community of inventors

Rueil Malmaison, France

Pierre Hugon