Dbv Technologies

Assistance Publique-hopitaux De Paris

Université Paris Descartes

Université De Paris

Universite Paris Cité

Université De Paris Cité

L'assistance Publique - Hopitaux De Paris

Pierre-Henri Benhamou

Christophe Dupont

Bertrand Dupont

Lucie Mondoulet

Stefan (Johan) Koppelman

Laurent Martin

Hervé Brochard

Estelle Foucher

Pierre-Yves Vannerom

Jorge Ronco

Stephane Benhamou

Vincent Dioszeghy

Stefan (johan) Koppelman

The present application relates to a method for desensitization of allergic patients. More specifically it relates to an epicutaneous desensitization method, applicable to any type of allergens and of patients. The method of the invention is essentially non-invasive and does not require the use of adjuvants. Further, it may be easily applied and monitored by the actual patient.

Allergen desensitization method

The invention relates to novel compositions and methods for diagnosing or treating food allergies. The invention particularly discloses new approaches for delivering food allergens to allergic patients by oral administration of formulations which dissolve and release proteins in the stomach. The invention allows the treatment of food allergies by delivering food allergens to the gut immune system with controlled exposure of the esophagus or oral cavity. The invention also allows to perform food challenges to assess the threshold of clinical reactivity without exposing the esophagus and oral cavity. The invention may be used in any subject, particularly human subjects, and is applicable to any food allergen.

Compositions of food allergens

Compositions for delivery of food allergens to the stomach

The present invention relates to the treatment of EE. More specifically, the invention relates to a new method of treating EE through the epicutaneous route. In particular, the method of the invention comprises applying to the skin of the subject a skin patch device, comprising a composition, under conditions allowing a contact between said composition and the skin. The present invention also relates to the skin patch device and to a use of the skin patch device in the manufacture of a composition for treating eosinophilic esophagitis in a subject.

Method of treating eosinophilic esophagitis

The present invention describes a new method for progressive desensitization of a subject to groundnut. More specifically, the invention relates to the immunotherapeutic method for increasing groundnut tolerance in an allergic subject using epicutaneous administration. The present invention is also relative to the use of a skin patch device for progressive desensitization of a subject to groundnut.

Immunotherapeutic method for increasing groundnut tolerance in a subject

A patch comprises a support having electrostatic properties. The periphery of the support is coated with an adhesive material, and all or part of the non-adhesive surface of the support is directly covered with at least one biologically active substance in the form of particles. The particles remain in contact with the non-adhesive part of the support as a result of the electrostatic forces.

Patch for screening and sensitization state of a subject with respect to an allergen and use thereof

A patch comprising a support having electrostatic properties is provided wherein a periphery of the support is coated with an adhesive material, and all or part of the non-adhesive surface of the support is covered with at least one biologically active substance in the form of particles that is adhered to the non-adhesive part of the support by electrostatic forces.

Patches and uses thereof

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Paris, France

Pierre-Henri Benhamou