Choay, S.a.

Agence Nationale De Valorisation De La Recherche (anvar)

Agence Nationale De Valorisation

Pierre G Sinay

Jean Choay

Maurice Petitou

Jean-Claude Lormeau

Jean-Claude Jacquinet

Louis A Chedid

Pierre Lefrancier

Edgar Lederer

Francoise Marguerite Audibert

Jean-Francois Petit

Arlette Adam

Rita Ciorbaru

Claude Merser

Fabrielle Ellouz

Dominique Juy

Ten Feizi

Mahmoud Nassr

Hock C Gooi

The invention relates to derivatives with a uronic acid structure having substituents selected among a reactive group, a functionalisable group and --OH functions blocked by protective groups. These derivatives are useful for preparing glycosides, particularly enzyme substrates.

Derivatives of the uronic acid

Novel processes for synthesizing acid mucopolysaccharide fragments having from 2-12 saccharides and substantially pure products of a single structure produced thereby. Condensation are disclosed between a first protected saccharide and a second protected saccharide to form a protected condensation product having units linked in the manner found in chondroitin sulfate and dermatan sulfate and having protecting groups thereon which allow selective positioning of functional groups, in particular sulfate, at desired positions. Other condensations are disclosed in which a protected condensation product is formed which can be elongated, and has protecting groups thereon which allow selective positioning of functional groups, in particular sulfate, at desired positions. Also disclosed is a process for selectively positioning functional groups on a protected acid mucopolysaccharide having from 2-12 units.

Method for carrying out the organic synthesis of oligosaccharides

The invention relates to a process for the organic synthesis of oligosaccharides constituting or comprising fragments of acid mucopolysaccharides comprising the reaction of two compounds constituted or terminated by units of glucosamine structure and of uronic acid structure respectively, said units being specifically substituted. This process particularly enables valuable anticoagulant drugs to be obtained.

Process for the organic synthesis of oligosaccharides and derivatives

The oligosaccharides of the invention contain or are constituted by a tetrasaccharide enchainment of the formula: ##STR1## in which R.sub.1 represents an organic anion, R.sub.2 is identical to R.sub.1 or represents a hydrogen atom, N.sub.1 and N.sub.2 represent a functional amino group.

Oligosaccharides and their biological applications

1,4.alpha.disaccharides of formula: ##STR1## with Z representing a nitrogenous functional group,

Disaccharides formed by patterns having a glucosamine and uronic acid

1,4 .alpha. disaccharides of formula: ##STR1## with Z representing a nitrogenous functional group,

Disaccharides having a glucosamine and uronic acid structure, and

The invention relates to substitution derivatives of trisaccharide 3-fucosyl-N-acetyl lactosamine and to the immunological applications of these derivatives and of the trisaccharide itself particularly as diagnostic reagent and in therapy.

3-Fucosyl-N-acetyl lactosamine derivatives, and their biological

Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens, comprising an acyl-muramic acid group, wherein acyl means acetyl or glycolyl, and a short peptide chain linked to said acyl-muramic acid group, the first and second amino acids of said peptide chain being preferentially alanine and glutamic acid respectively.

Growing community of inventors

Orleans, France

Pierre G Sinay