Novartis Animal Health Us, Inc.

Novartis Ag

Elanco Tiergesundheit Ag

Other

Novartis Pharma Gmbh

Pierre Ducray

Thomas Goebel

Jacques Bouvier

Noëlle Gauvry

Chouaib Tahtaoui

Ronald Kaminsky

Pascal Furet

Francois Pautrat

François Pautrat

Tania Cavaliero

Martin Jung

Jorg Fruchtel

Corinne Durano

Denise Rageot

Maurizio Schwarzenbach

Maike Lohrmann

Urs M&uuml;ller

Corina Bergamin

Matthias Keller

Maike Renner

Noeelle Gauvry

The present invention provides compounds of formula (I):

Bicyclic derivatives for treating endoparasites

The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful as therapeutic agent for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis. Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, inflammatory bowel diseases, Crohn's disease, Alzheimer's disease, leukemia, osteoarthritis, control of pruritus, chronic respiratory disease or keratoconjunctivitis in mammals. 

Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors

The invention relates to a compound of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful as therapeutic agent for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, inflammatory bowel diseases, Crohn's disease, Alzheimer's disease, leukemia, osteoarthritis, control of pruritus, chronic respiratory disease or keratoconjunctivitis in mammals. 

Compounds

The present invention is directed to a non-therapeutical process for deterring vermin, which is based on the usage of the largely known beta amino-alcohol derivatives of formula (I) as described herein. Further, the present invention is directed to corresponding vermin-deterring compositions which contain these substances as the active ingredient, compounds of the formula (I) for the preparation of vermin-deterring compositions, and the use of compounds of formula (I) in the defense against vermin.

Composition for repelling and deterring vermin

The invention describes essentially a non-therapeutical process for deterring vermin, which is based on the usage of the largely known beta amino-alcohol derivatives of formula (I), as defined herein before. Furthermore, it describes the corresponding vermin-deterring compositions which contain these substances as the active ingredient, compounds of the formula (I) for the preparation of vermin-deterring compositions, and the use of compounds of formula (I) in the defense against vermin. Thus, the invention describes how and in which form the compounds of the formula (I) or their acid addition salts are used to deter vermin from materials, places or warm-blooded animals. 

The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claimand optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals. 

Amidoacetonitrile derivatives

The invention relates to compounds of the general formula wherein either R signifies C-C-alkyl, halo-C-C-alkyl, C-C-alkoxy-C-C-alkyl or halo-C-C-alkoxy-halo-C-C-alkyl; and Xsignifies a single bond, O, S, S(O) or S(O); or R signifies halogen and Xsignifies a single bond; Xsignifies CN, halogen, C-C-alkyl, halo-C-C-alkyl, C-C-alkoxy, halo-C-C-alkoxy, C-C-alkoxycarbonyl, C-C-alkylthio, C-C-alkylsulfinyl, C-C-alkylsulfonyl, C-C-alkylsulfonylamino, halo-C-C-alkylsulfonylamino, OH, NH, COOH, CONH, C-C-alkylaminocarbonyl or C-C-alkylcarboxamido, whereby if n is greater than 1, Xmay differ from each other; m signifies 1, 2, 3 or 4; and n is 1, 2, 3, 4 or 5, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.

The invention relates to compounds of the general formula and optionally the enantiomers thereof. These compounds have advantageous pesticidal properties. They are especially suitable for controlling parasites in warm-blooded animals.

Benzamidoacetonitriles and their use as antiparasitics

The invention relates to the use of aminoacetonitrile compounds of formula (I), wherein R, R, R, R, R, R, A, m and n have the significances given in claim, in the control of endoparasites, especially helminths, in warm-blooded productie livestock and domestic animals.

Organic compounds

The invention relates to aminoacetonitrile compounds of the formula wherein m is 1, 2 or 3;

Aminoacetonitrile compounds for controlling endoparasites

The invention relates to compounds of the general formula (I) wherein Ar, R, R, R, R, R, R, R, R, R, R, W, a, b, m, n, o and p are as defined in claim, and to any enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are particularly suitable for controlling parasites in warm-blooded animals.

Aminoacetonitrile derivatives and their use for controlling parasites on warm-blooded animals

The invention relates to compounds of the general formula (I), wherein R, R, R, R, R, R, R, R, R, R, W, a, b and n have the significances given in claim, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals. 

Aminoacetonitrile derivatives suitable for controlling parasites

The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claim 1 and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals. 

The invention is directed at a new process for the preparation of pure enantiomers from the racemate of amidoacetonitrile compounds of formula wherein

Process for the preparation of enantiomers of amidoacetonitrile compounds from their racemates

The invention relates to compounds of the general formula in which R, R, R, R, R, W, X, A, A, a, b and c are as defined in the specification, and to any enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are particularly suitable for controlling parasites in warm-blooded animals.

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Village-Neuf, France

Pierre Ducray