Sanofi-aventis

Sanofi

Elf Sanofi

Pierre Despeyroux

Daniel Frehel

Jean-Pierre Maffrand

Paul De Cointet

Alain Badorc

Danielle Gully

Claudine Serradeil-Le Gal

Gilles Courtemanche

Jean-Pierre Bras

Daniele Anne Gully

Pierrick Rochard

Evelyne Fontaine

Robert Boigegrain

Bruno Schoentjes

Viviane Van Dorsselaer

Eric Bignon

Rebecca Pruss

Corinne Heckel

Chantal Guenet

The present invention is directed to a compound of formula (I): wherein Ar, Ar, Ar, R1 and T are as defined herein, its preparation, pharmaceutical composition and uses as orexin 2 receptor antagonist.

Sulfonamide derivatives, preparation thereof and use thereof as antagonists of orexin 2 receptors

Compound corresponding to the general formula (I): in which, where Rrepresents a hydrogen atom or a Calkyl; n represents an integer ranging from 0 to 3; and Rrepresents, independently of each other when n=2 or 3, a hydrogen or halogen atom, a hydroxyl, Calkyl, Calkoxy, Cfluoroalkyl or Cfluoroalkoxy group;in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. therapeutic application.

Acylaminothiazole derivatives, their preparation and their therapeutic use

Disclosed are compounds having the general formula (I) as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barr&#xe9; syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

Sulphonamide derivatives, their preparation and their therapeutic application

The invention concerns a compound of general formula (I), wherein: X represents an oxygen or sulphur atom; Rrepresents, independently of each other when n=2 or 3, a halogen atom, a hydroxy, a C-Calkyl, a C-Calkoxy, a trifluoromethyl, a trifluoromethyloxy or a methylenedioxy; Rrepresents a C-Calkyl group optionally substituted, a C-Ccycloalkyl, piperidinyl or phenyl group, the C-Ccycloalkyl, piperidinyl or phenyl groups being optionally substituted; Rrepresents a hydrogen atom or a C-Calkyl group optionally substituted; Rrepresents a hydrogen atom or a C-C4 alkyl group; and Rand Rrepresent, independently of each other, a hydrogen atom, a hydroxy, a halogen atom, a C-Calkyl group, or Rand Rform together an oxo group; Rrepresents a hydrogen atom, a halogen atom, a C-Calkyl, a C-Calkoxy, a trifluoromethyl, or a trifluoromethoxy; in the form of a base, addition to an acid, hydrate or solvate. The invention is applicable in therapy 

Acylaminothiazole derivatives, their preparation and therapeutic use

The invention relates to the compounds of formula (I) ##STR1## in which R.sub.I, R.sub.II, X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are as defined in claim 1.

Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one

The present invention relates to compounds of formula: ##STR1## which are agonists of cholecystokinin receptors and pharmaceutical compositions containing them.

Glycinamide derivatives, processes for their preparation and medicines

Polysubstituted 3-acylamino-5-phenyl-1, 4-benzodiazepin-2-one

The invention relates to thiadiazole derivatives corresponding to the general formula ##STR1## in which Ar represents a nitrogen-containing aromatic heterocycle, in particular indolyl which is substituted or unsubstituted on the nitrogen atom with CO--(C.sub.1 -C.sub.4)alkyl; with (CH.sub.2).sub.n COR in which n represents 1 or 2 and R represents OR.sub.1 or NR.sub.1 R.sub.2 with R.sub.1 and R.sub.2, which may be identical or different, representing H or (C.sub.1 -C.sub.4)alkyl; with (C.sub.1 -C.sub.4) hydroxyalkyl; with (C.sub.2 -C.sub.6) alkoxyalkyl; tetrahydropyranyl; or with a --(CH.sub.2).sub.3 -- chain, the last carbon of which is attached to the phenyl ring of the indole to form a 6-membered ring;

5-acylamino-1,2,4-thiadiazoles, their preparation and pharmaceutical

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Antony, France

Pierre Despeyroux