Smithkline Beecham Biologicals S.a.

Abay S.a.

Pierre Desmons

Pierre Hauser

Nathalie Marie-Josephe Garcon

Moncef Mohamed Slaoui

Pierre Voet

Nathalie Marie-Josephe Garcon-Johnson

Nathalie Marie-Josephe Claude Garcon

Philippe Mullier

Moncef Slaoui

A novel vaccine formulation is provided, comprising a hepatitis B component, particularly hepatitis B surface antigen, in combination with aluminum phosphate and 3 de-O-acylated monophosphoryl lipid A.

Hepatitis B vaccine

Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A

A process is provided for the purification of pertussis toxin (PT) and/or filamentous hemagglutinin antigen (FHA) from a B. pertussis fermentation broth or cell free culture supernatant containing at least one antigen, which comprises contacting the fermenation broth or cell free culture supernatant with a hydroxyapatite adsorbent for a sufficient time to adsorb the antigen(s) at a pH which both PT and FHA are adsorbed and eluting a mixture containing the adsorbed antigen(s) from the adsorbent with eluant at a pH which both PT and FHA are eluted. The PT and FHA may be further purified by two sequential chromatographic columns, one of which involves apolar-ligand chromatography.

Method for isolating and purifying bordetella pertussis antigenic factors

A fermenter cell disposed so that the primary axis of the cell is approximately horizontal comprises solid partitions, arranged perpendicularly to the primary axis, which separate the cell into several chambers. The partitions are provided with apertures, each at a predetermined height, which allow liquid to pass; in addition, gas evacuation pipes are provided in the upper part of the chambers.

Fermentation cell for continuous operation

Growing community of inventors

Nivelles, Belgium

Pierre Desmons