Amgen Inc.

Hoechst Marion Roussel

Galapagos Sasu

Other

Roussel Uclaf

Aventis Pharma S.a.

Galapagos Sas

Pierre Deprez

Jacques Guillaume

Michel Fortin

Alain Corbier

Bertrand Heckmann

Jacques Dumas

Hélène Jary

Taoues Temal

Christopher Harold Fotsch

Paul E Harrington

Marie-Claude Fournie-Zaluski

Sarah Lively

Kanaka Pattabiraman

David St Jean

Bernard Pierre Roques

Marcel Patek

Taoues Temal-Laib

Helène Jary

The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes. 

Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

The present invention provides compounds of formula (I): in which R, R', R, R&#x2032;, R, Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them. 

Urea derivatives methods for their manufacture and uses thereof

The present invention provides compounds of Formula (I): in which R, R', R, R&#x2032;, R, and Y have the meanings given in the description are useful in the treatment of conditions susceptible to modulating ion channels, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

Urea derivatives, processes for their preparation, their use as medicaments, and pharmaceutical compositions containing them

The invention relates to new products of formula (I):  

Urea derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use

Products of formula (1), wherein R is particularly phonyl or biphenyl optionally substituted by halogen n1 and n2 are 0 or 1, R is particularly hydrogen or methyl substituted by phenyl, which may in turn be substituted, and A is partcularly carboxy or alkyl substituted particularly by phenoxy, as well as all isomers and organic and inorganic base addition salts therof, are disclosed.

Sulphur derivatives with a retroamide bond as endothelin-converting enzyme inhibitors

Sulphur derivatives comprising an amide bond, method for preparing same,

Products of formula (1), wherein R.sub.1 is particularly ##STR1## alkyl, alkylthio or alkoxy; R.sub.2 is particularly halogen, --S--R, --O--R or --C(OH)(R)--COOH, where R is alkyl or alkenyl; R.sub.3 is particularly carboxy, acyl, halogen, alkyl, alkenyl or alkylthio; and R.sub.4 is particularly --(CH.sub.2).sub.m1 --COOR.sub.4, --(CH.sub.2).sub.m1 --CONHR.sub.14, --(CH.sub.2).sub.m1 --CN, --SO.sub.2 --NH--SO.sub.2 --R.sub.14, 13 NH--SO.sub.2 --R.sub.14, --PO.sub.3 R.sub.14, or --NH--SO.sub.2 --CF.sub.3, where m1 is 0-4 and R.sub.14 is hydrogen, alkyl or alkenyl; are useful for preparing pharmaceutical compositions for treating disorders resulting from abnormal stimulation of angiotensin II receptors AT.sub.1 and AT.sub.2.

Imidazole-5-carboxamides

Method of preventing abnormal stimulation of AT.sub.1 and AT.sub.2

Tetrasubstituted imidazoles

Growing community of inventors

Thiais, France

Pierre Deprez