The Genetics Company, Inc.

Unversität Zürich

Pierre Daram

Frank Jaschinski

Leonardo Scapozza

Barbara Froesch

Ernst Hafen

Gabriel Garcia

Guy Lemaillet

Cornelia Marty-Ernst

Elena Marzi

Hugo Stocker

Benno Shindelholz

Sebastian Breuer

The present invention relates to the use of a sulfonamide compound of formula (I): wherein Ris selected from the group consisting of H, CN, halogen, trifluoromethyl, methyl, ethyl, hydroxy, methoxy, ethoxy, morpholino, Ris selected from H, phenyl, substituted phenyl, CN, &#x2014;SOR, wherein R is phenyl or morpholino, &#x2014;NC(O)Me, &#x2014;NC(O)Et, &#x2014;CHC(O)OMe, CHC(O)OEt, Ris selected from the group consisting of H, NO, NH, halogen, &#x2014;COOMe, &#x2014;COOEt, RC(O)N&#x2014;, morpholino, Ris selected from the group consisting of H, a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, methoxy, ethoxy, propoxy, butoxy, a substituted or unsubstituted phenyl, alkinyl, MeSO&#x2014;, COOR, wherein R is a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, -MeOC(O)&#x2014;, a substituted or unsubstituted five or sixmembered aromatic or non-aromatic heterocyclic system with one, two or three heteroatoms, a hetaryl system, a condensed benzoheterocyclic system, X is a linker comprising 2 or 3 atoms, selected from the group consisting of &#x2014;NH&#x2014;NH&#x2014;, &#x2014;NH&#x2014;NH&#x2014;CH2&#x2014;, ethinyl, &#x2014;NH&#x2014;C(O)&#x2014;CH&#x2014;, &#x2014;NH&#x2014;NH&#x2014;SO&#x2014;, &#x2014;C(O)&#x2014;NH&#x2014;CH&#x2014;, &#x2014;NH&#x2014;N&#x2550;CH&#x2014;, &#x2014;NH&#x2014;N&#x2550;C(Me)-, a &#x2014;NH&#x2014;N&#x2550;CH&#x2014; motif being part of a heterocyclic system, preferably a substituted or unsubstituted pyrazole or pyridazine system, and pharmaceutically active salts thereof. Further, the invention relates to the use of these compounds as a medicament, especially for the treatment of cancer. 

Sulfonamides and their use as a medicament

The application discloses a new family of proteins, namely the epsin like proteins (ELP). Said proteins comprise an ENTH domain (Epsin NH2 Terminal Homology domain) and have growth inhibiting activity. The disclosed proteins can be used for the diagnosis of hyperproliferative diseases as well as for gene therapy purposes.

Growth regulating proteins

Growing community of inventors

Uetikon am See, Switzerland

Pierre Daram