University of Washington

University of Massachusetts

Physiosonics, Inc.

Other

University of Pittsburgh

Allez Physionix, Ltd.

Aller Physionix Limited

Pierre D Mourad

Patrick S Stayton

Lawrence A Crum

Allan Sachs Hoffman

Niren Murthy

David A Tirrell

Oliver Press

Michel Kliot

Tyrone M Porter

Rex Patterson

Chantal Lackey Reed

Anthony Convertine

Richard Glen Ellenbogen

Forrest M Kievit

Donghoon Lee

Alec Rooke

Adeyinka Adedipe

Graham Nichol

Julia Mengyun Xu

Menko P Ypma

Peter A Chiarelli

Joshua Sang Hun Park

Matthew David Klein

Buddy D Ratner

Samuel R Browd

Jason Leonard Seawall

Brian E MacConaghy

John Kucewicz

Roger Lee Thompson

Antao Chen

Mohammad Hassan Arbab

Dale P Winebrenner

Nathaniel Coulson

Matthew Sundermann

David Salcido

Connie Sau-Kuen Kwok

Chantal Lackey

Jeffrey G Jarvik

Ali Mesiwala

Francis G Olson

Robert C A Frederickson

Brandt Mohr

Revathi Murthy

Trevor C Dickey

Brian Macconaghy

Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Oxygen reactive polymers for treatment of traumatic brain injury

In some embodiments, a blood flow sensor device such as a non-invasive cardiac arrest monitor (NICAM) that uses ultrasound to detect blood flow is used to monitor blood flow during cardiopulmonary resuscitation. One or more gating signal generation devices transmit gating signals to a blood flow monitoring computing device. The blood flow monitoring computing device uses the gating signals to determine time periods during which blood flow information generated by the blood flow sensor device is most likely to be accurate. The blood flow monitoring computing device measures blood flow during the time periods. In some embodiments, the blood flow monitoring computing device presents the measured blood flow to a user. In some embodiments, the blood flow monitoring computing device transmits a command to a chest compression device based on the measured blood flow.

System and method of noninvasive blood flow measurement during cardiopulmonary resuscitation using signal gating

A medical device for providing guidance to administered cardiopulmonary resuscitation during cardiac arrest in a subject comprising a measuring probe to measure a hemodynamic property of blood flowing through a blood vessel of the subject, an interface element with reference indicia to guide the measuring probe to major blood vessels of the subject experiencing cardiac arrest, and a blood flow monitoring device comprising a data module to collect measured hemodynamic properties of the subject and a guidance module configured to display resuscitation guidance information for manipulating at least one hemodynamic property of the blood.

Device and method for guiding cardiopulmonary resuscitation during cardiac arrest

A stylet () includes a handle assembly () with an indicator display () and a stiff wire assembly () extending distally from the handle assembly () having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser (), a transmit/receive chip (), a bandpass filter (), a differential amplifier (), an ADC (), and an MCU (), operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.

Ultrasound stylet

The present invention provides methods, software, and systems for assessing a burn injury.

Methods and systems for assessing a burn injury

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophoresis can also be used with the disrupting agents.

Enhanced transport using membrane disruptive agents

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents.

Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.

Systems and methods for determining blood pressure

Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.

Methods for determining intracranial pressure non-invasively

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.

A power toothbrush () is disclosed having a handle () containing a rechargeable battery (), an ultrasonic drive circuit (), a sonic component () such as a motor, and a control unit (). The handle is connected to a toothbrush head () preferably having a plurality of bristles () and an ultrasonic transducer () that is operatively connected to a waveguide () that extends from the toothbrush head generally adjacent the bristles. The waveguide facilitates the transmission of acoustic energy into the dental fluid. It is contemplated that the waveguide may be utilized in manual or power toothbrushes, and in a combination without the sonic component, or in a combination without the ultrasonic transducer. Toothbrushes disclosed herein achieve improved plaque and stain removal from the teeth as well as interproximal and subgingival regions, while enhancing the user experience, massaging the gums, and stimulating dental tissue.

Toothbrush employing an acoustic waveguide

Systems and methods for making noninvasive assessments of cardiac tissue and parameters

Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties. Methods and systems for localizing physiological condition(s) and/or biological response(s), such as pain, by targeting and selectively probing tissues using the application of focused ultrasound are also provided.

Systems and methods for making noninvasive physiological assessments

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Seattle, WA, United States of America

Pierre D Mourad