Centre National De La Recherche Scientifique

Pierre Champy

Bruno Figadere

Fanny Schmidt

Xavier Franck

Rita Raisman-Vozari

Sylvia Rita Vozari

The invention relates to a compound of the following formula (I), 

Indole derivatives for treating neurodegenerative diseases

The present invention relates to compounds of Formula (I) below, to their pharmaceutically acceptable salts and to their isomers or mixtures of isomers: HetAr&#x2014;X&#x2014;CHRR(I) in which: &#x2014;HetAr represents a group chosen from: &#x2014;X represents a linear, saturated or unsaturated, hydrocarbon-based chain comprising from 8 to 22 carbon atoms, optionally interrupted by an &#x2014;NH&#x2014; or &#x2014;NH&#x2014;CO&#x2014; group, &#x2014;Rrepresents a hydrogen atom or an &#x2014;OH, &#x2014;O(C-C)alkyl, &#x2014;OCO((C-C)alkyl), &#x2014;OSO((C-C)alkyl) or &#x2014;OSOH group, and &#x2014;Rrepresents a hydrogen atom or a (C-C)alkynyl, (C-C)alkenyl or (C-C)cycloalkyl group. The present invention also relates to a process for preparing the compounds of Formula (I), and also to the use thereof, especially in the treatment of neurodegenerative diseases. 

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Palaiseau, France

Pierre Champy