Societe De Conseils De Recherches Et D'applications Scientifiques

Ludwig Institute for Cancer Research Limited

Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Departemente D'immunologie Institut Henri Beaufour

Department D'immunologie Institut Henri Beaufour

Societe De Conseils De Recherches Et D'application (s.c.r.a.s.)

Pierre Braquet

Colette Broquet

Andre Esanu

Jean-Jacques Godfroid

Francoise Heymans

Pierre-Etienne Chabrier De Lassauniere

Serge Auvin

Jean-Pierre Laurent

Jean-Christophe Renauld

Jacques Van Snick

Catherine Uyttenhove

Catherine Druez

Eduardo Pirotzky

Bernard Dugas

Jean M Mencia-Huerta

Benedicte Vandamme

Paola Principe-Nicolas

Michel Auguet

Jacques Pommier

Alain Rolland

Peter W Ramwell

Christiane Martin

Georges Dive

Jean-Michel Guillon

Denis Bigg

Treating disorders characterized by excessive cell proliferation with

The invention relates to thieno-triazolo-diazepine derivatives of the formula: ##STR1## wherein Y stands for oxygen or sulphur and R stands for various substituents, to a preparation process of said compounds and to therapeutic compositions containing the same. The compounds are particularly interesting as anti-asthmatic, anti-allergic and gastro-intestinal protectors.

Derivatives of thieno-triazolo-diazepine and therapeutic compositions

The invention relates to compounds of the general formula AB, which may be a salt or an amide, wherein: A represents a cyclooxygenase inhibitor having an accessible acidic function and B represents the L-form of arginine analogues of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 represent various substituents, process for the preparation of such compounds and pharmaceutical composition thereof.

Dual inhibitors of NO synthase and cyclooxygenase, therapeutical

The invention relates to a N-(2,4- or 2,5-disubstituted tetrahydrofuryl alkyl)-N-(phenylethyl-.beta.-ol)amine derivative, under a racemic or enantiomer form, of general formula I ##STR1## wherein R represent various radicals and n is of from 1 to 10, to a process for the preparation of said derivative, and to pharmaceutical compositions comprising the same.

N-derivatives of (phenylethyl-.beta.-ol) amine, a process for their

The invention relates to compounds of the general formula AB, which may be a salt or an amide, wherein:

Dual inhibitors of no synthase and cyclooxygenase, process for their

A method for inhibiting production of IgE, and a method for enhancing production of IgG are taught. The methods are linked to the role of interleukin 9 in antibody production. Specifically, production of IgG is potentiated by administering either to a subject or a cell culture a combination of interleukin 4 and interleukin 9. Production of IgE is inhibited by administering an amount of an interleukin 9 inhibitor to a subject.

Method for inhibiting production of IgE by using IL-9 inhibitors

The invention relates to pyrrolo-pyridine derivatives of the formula: ##STR1## wherein R represents a phenyl group, optionally substituted by one or more of various groups and therapeutically acceptable salts of these compounds, to a preparation process of the same comprising reacting, in an inert atmosphere and in a protic solvent, the 2-methyl 3-hydroxy 4,5-diboromomethyl pyridine, on a stoichiometric excess of the compound of the formula NH.sub.2 -R. The invention relates also to therapeutic compositions containing said derivatives as active ingredient. The compounds according to the invention have antiallergic activity.

Pyrrolo-pyridine derivatives and therapeutic compositions containing them

A method for inhibiting blood vessel blockage in a mammal particularly after a procedure such as angioplasty, an arterial bypass operation or an allograft transplant operation which comprises: administering to a mammal before, during and/or after the procedure an effective blood vessel blockage inhibiting amount of an octapeptide having the formula ##STR1## wherein each A.sub.1 and A.sub.2, independently, is H, C.sub.1-12 alkyl, C.sub.7-10 phenylalkyl, R.sub.1 CO (where R.sub.1 is C.sub.1-20 alkyl, C.sub.3-20 alkenyl, C.sub.3-20 alkinyl, phenyl, naphthyl, or C.sub.7-10 phenylalkyl), or R.sub.2 OCO (where R.sub.2 is C.sub.1-10 alkyl or C.sub.7-10 phenylalkyl), provided that when one of A.sub.1 or A.sub.2 is R.sub.1 CO or R.sub.2 OCO, the other must be H; A.sub.3 is CH.sub.2 A.sub.6 (where A.sub.6 is pentafluorophenyl, naphthyl, pyridyl, or phenyl); A.sub.4 is o-, m- or, more preferably, p-substituted X-Phe (where X is a halogen, H, NH.sub.2, NO.sub.2, OH , or C.sub.1-13 alkyl), pentafluoro-Phe, or .beta.-Nal; A.sub.5 is Thr, Ser, Phe, Val, .alpha.-aminobutyric acid, or Ile; A.sub.7 is Thr, Trp, or .beta.-Nal (and can be either the D- or L-isomer); and Z is NH.sub.2 or OH; or a pharmaceutically acceptable salt thereof.

Method for inhibiting blood vessel blockage using octapeptide

Method for inhibiting production of IGE and method for enhancing

The invention relates to 3-(N-methyl-N-alkyl)-amino 2-methoxymethylene propan 1-ol derivatives of the formula ##STR1## wherein R stands for an alkyl chain, A stands for: ##STR2## and Y represents various quaternary ammonia, to a preparation process of said compounds and to therapeutic compositions containing the same.

3-(N-methyl-N-alkyl)-amino 2-methoxymethylene propan 1-ol derivatives, a

The invention relates to glycerol derivatives of general formulae Ia, Ib and Ic ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, A and Y stand for various substituents, to a preparation process of said compounds and to therapeutical compositions containing the same.

Glycerol derivatives, and therapeutical compositions containing them

The invention relates to a therapeutical composition of matter for the treatment by perfusion of shock states comprising as an essential ingredient therein, an effective amount either, of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.4 stant for H or CH.sub.3 or C.sub.2 H.sub.5,

Blocking agents of EDRF effect or formation for the treatment of shock

The invention relates to new selenophen derivatives of the formulae, ##STR1## to a preparation process of said compounds and to therapeutic compositions containing the same.

Selenophen derivatives, a preparation process of the same and

This invention relates to thieno-triazolo-diazepine derivatives of the formula ##STR1## wherein R represents various substituents, to a preparation process of these compounds consisting in reacting the thieno-triazolo-diazepine compound of the formula ##STR2## on RSO.sub.2 Cl and to therapeutic compositions containing the same. The compounds are particularly interesting as anti-PAF and anti-ischemic agents.

Sulfonyl derivatives of thieno-triazolo-diazepines useful as anti-PAF

The invention relates to thieno-triazolo-diazepine derivatives of the formula ##STR1## wherein Y stands for oxygen or sulphur and R stands for various substituents, to a preparation process of said compounds and to therapeutic compositions containing the same. The compounds are particularly interesting in the treatment of ischemia.

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Garches, France

Pierre Braquet