Other

Insa Rouen

Gous Inc.

Centre National De La Recherche Scientifique

UniversitÉ´de Rouen

Vfp Therapies

Insa (institut National Des Sciences Appliquees) De Rouen

Pierre Bohn

Vincent Levacher

Francis Marsais

Nicolas Le Fur

Vincent Gembus

Cyril Papamicael

Ludovic Peauger

Marie-Laurence Dumartin-Lepine

A compound of formula (I) in which the dotted lines indicate the presence of at least one double bond; n=0 to 4; Rand Rare H, or when n=1, Rand Rcan also form together a double bond between the carbon atoms, and m=0, 1 or 2, Z is CH or N or Z is C and &#x2014;CHR&#x2014; is &#x2550;CH&#x2014; linked by the double bond to cyclopentanone; or &#x2212;(&#x2212;)- is absent, and Z is NH, &#x3e;N-alkyl, &#x3e;N-phenyl, &#x3e;N-benzyl or &#x3e;N heteroaryl; Ris alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR', CN, COR, CF, SOR, SOR, SONRR&#x2032;, SONRR&#x2032;, NO, halogen, heteroaryl; and the pharmaceutical salts and stereisomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease. 

Oxidisable pyridine derivatives, their preparation and use as anti-alzheimer agents

The invention is related to compound which comprises at least one radical C&#x2550;Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one carbon atom of the radical group C&#x2550;Y and the nitrogen atom, when oxidized, is comprised between 0.3 and 0.8 nanometers. The invention is related to new heterocyclic compounds defined by formula G, their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of neurodegenerative or Alzheimer disease. 

Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents

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Rouen, France

Pierre Bohn