Rhone-poulenc Sante

Flamel Technologies

Rhone-poulenc Nutrition Animale

A.e.c. Societe De Chimie Organique Et Biologique

Financiere Elysees Balzac

Pierre Autant

Andre Cartillier

Jacques Ruel

Paul Bourrain

Raymond Pigeon

Rafael Jorda

Gerard Soula

Stephen H Wu

Stephen Weinhold

Charles A McCombs

Hugues Porte

Robert E Sparks

Jean-Pierre Quentin

Norbert S Mason

Jean-Luc Wertz

Ernest Phillip Smith

Pierre Ardaillon

Alain Sabatier

Jean-Philippe Selles

Christophe Chalvin

Claudine Colin

Rafaël Jorda

Claude Annonier

Jean-Claude Laffay

Louis P Hoskins

Rossin Rene

A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40&#xb0; C. and 120&#xb0; C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.

Compressed tablets comprising microcapsules with modified release

The invention relates to a composition, in pellet form, useful for the nutritional and/or medicinal supplementation of ruminants and a method for admixing the pellets with foodstuff. The pellet contains granules of one or more active ingredients/principles protected against degradation in toe rumen and one or more binding agents capable of being solubilized, crosslinked or melted. Optionally, the pellet may also contain an unprotected active ingredient for release in the rumen. The pellet may further contain a disintegrating agent and/or filler.

Pellets containing active ingredients protected against degradation in the rumen of ruminants

The present invention relates to microcapsules for the oral administration of medicinal and/or nutritional active principles (AP), which are smaller than or equal to 1000 .mu.m in size. These microcapsules consist of particles which are coated with a coating material consisting of a mixture of a film-forming polymer derivative, a hydrophobic plasticizer, a functional agent and a nitrogen-containing polymer. These microcapsules are also characterized by their ability to remain in the small intestine for a long time (at least 5 hours) and to allow, during the residence, release and absorption of the AP. The invention also relates to a process for the production of the said microcapsules.

Medicinal and/or nutritional microcapsules for oral administration

The invention relates to microcapsules containing at least one active ingredient, characterized in that they are constituted by:

Microcapsules containing at least one active ingredient, application of

The present invention relates to a cellular cellulosic material containing a biocide agent and to a process for preparing same. Characteristically, matrix type microparticles, containing at least one biocide agent, are distributed in the network of cellulose of said material, ensuring therein, in the presence of moisture or water, a controlled release of the biocide agent or agents.

Cellular cellulosic material containing a biocide agent and process for

The present invention relates to new granules, as well as the process for their preparation, obtained by extrusion of a mixture containing a meltable binder in an amount such that it permits the passage of the mixture through a die. The granules obtained are then coated with a polymer permitting their trans-rumen passage without degradation. After coating, these granules are used for animal feeding of ruminants.

Extrusion of an admixture of a meltable binder and a food or drug

A composition which is stable in a medium in which the pH is greater than or equal to 5.5 and which permits the release of an active substance in a medium in which the pH is less than or equal to 3.5, comprising the active substance, which contains inclusions of, or which is completely or partially covered by, a pH sensitive material whose extent and/or rate of swelling is greater in an acidic medium than in a neutral medium, and a coating of a hydrophobic layer.

Composition for feeding ruminants

A composition for coating a biologically active substance, which is stable in a medium with a pH greater than or equal to 5 and which enables the active substance to be released in a medium with a pH less than or equal to 3.5, consisting of a basic amino copolymer (preferably vinyl-pyridine/styrene copolymer) and a hydrophobic substance with a melting point greater than 60.degree. C. (preferably stearic acid), the hydrophobic substance content being between 50 and 90% of the total mass of the coating, and granules comprising a nucleous containing the biologically active substance, coated with this composition.

Compositions for coating feedstuff additives for ruminants and feedstuff

A composition for coating a biologically active substance which is stable in a medium in which the pH is greater than or equal to 5 and which permits the release of the active substance in a medium in which the pH is less than or equal to 3.5, comprises a film-forming, water-insoluble binder which possesses controlled hydrophilicity and is optionally slightly sensitive to pH variations, and a substance which is sensitive to pH variations (e.g. an inorganic filler, simple aminated substance, basic polymer or copolymer, chitosan). Pellets for feeding to ruminants consist of a core containing the biologically active substance, e.g. methionine or lysine, coated with this substance.

Compositions for coating feeding stuff additives intended for ruminants

Composition for feeding ruminants, containing a water-soluble biologically active substance which is stable in a medium whose pH is greater than or equal to 5 and which permits the release of the active substance in a medium whose pH is less than 3.5, comprising:

Composition for feeding ruminants containing a biologically active

Composition for coating a biologically active substance, which is stable in a medium of which the pH is greater than or equal to 5, and which permits the release of the active substance in a medium of which the pH is less than or equal to 3.5, and biologically active substances when surrounded by this composition.

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Commentry, France

Pierre Autant