The United States of America, As Represented by the Secretary, Department of Health and Human Services

Pierre Alusta

Jon Gardner Wilkes

Dan Alexander Buzatu

Richard D Beger

Ryan M Kretzer

Bruce Pearce

Cameron Dorey

Inessa Im

William Ryan Parker

A system and method for preprocessing magnetic resonance spectroscopy (MRS) data of brain tissue for pattern-based diagnostics is disclosed. The MRS preprocessing system includes an MRS preprocessing module that executes an operation that normalizes MRS spectrum data, recalibrates and scales the normalized MRS spectrum data, and then renormalizes the scaled MRS spectrum data. The resulting preprocessed MRS data is used to assist in identifying abnormalities in tissues shown in MRS scans.

System for magnetic resonance spectroscopy of brain tissue for pattern-based diagnostics

Disclosed is a mass spectrometer for analyzing a sample that has or is suspected of having microorganisms. The disclosed mass spectrometer has been uniquely configured to include a sample platform which functions as a counter electrode or discharge electrode and a surface to provide the sample to be analyzed. The mass spectrometer also includes an ion source positioned adjacent to the sample platform for ionizing and volatizing molecules within the sample, wherein the sample platform and the ion source are positioned such that during operation of the mass spectrometer an electrical discharge takes place between the ion source and the sample platform. Also disclosed are methods for generating a mass spectrum profile/fingerprint of a sample. The methods include positioning a sample platform having a sample adjacent to an ion source.

Direct impact ionization (DII) mass spectrometry

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Little Rock, AR, United States of America

Pierre Alusta