Imperial Chemical Industries Limited

Ici Pharma

Zeneca Limited

Other

Zeneca Pharma S. A.

Pierre A Bruneau

Graham C Crawley

Keith Oldham

David Waterson

Robert I Dowell

Keith H Gibson

Frank Carey

Christine M Lambert-van Der Brempt

Christian R Delvare

Rodger M McMillan

The invention concerns a bicyclic heterocyclic derivative of the formula I ##STR1## wherein Q is an optionally substituted 9-membered bicyclic heterocyclic moiety containing 1 or 2 N's and optionally a further N, O or S heteroatom;

Benzoxazolyl derivatives useful as 5-lipoxygenase inhibitors

The invention concerns a cyclic ether derivative of the formula I ##STR1## wherein Ar.sup.1 is optionally substituted phenyl, naphthyl or a 9- or 10-membered bicyclic heterocyclic moiety;

Pyran derivatives and their use as inhibitors of 5-lipoxygenase

The invention concerns a bicyclic heterocyclic compound of the formula I ##STR1## wherein Q is an optionally substituted 10-membered bicyclic heterocyclic moiety containing 1 or 2 N's and a further O or S heteroatom;

Pyridooxazinyl or pyridothiazinyl as inhibitors of leukotrienes

The invention concerns cycloalkane derivatives of the formula I ##STR1## wherein Ar.sup.1 is phenyl, naphthyl or a 10-membered bicyclic heterocyclic moiety which may optionally bear up to four substituents;

Cycloalkane derivatives

Indole derivatives as 5-lipoxygenase inhibitors

Benzothiaziny derivatives

Bicyclic heterocyclic derivatives as 5-lipoxygenase inhibitors

The invention concerns a thioxo heterocycle of the formula I ##STR1## wherein Q is a 10-membered bicyclic heterocyclic moiety containing 1 or 2 N's which bears 1 or 2 thioxo substituents and which is optionally further substituted;

Thioxo quinoline compounds, composition and method of use

The invention concerns a 1,2-dihydro-3H-indazol-3-one derivative of formula I ##STR1## wherein R.sup.a is hydrogen, halogeno, hydroxy, cyano, trifluoromethyl, (1-6C)alkyl or (1-6C)alkoxy;

4-carbamoyl-1,2-dihydro-3H-indazol-3-one derivatives

Benzoxazine derivatives as inhibitors of leukotrienes

The invention concerns pharmaceutical compositions containing a 1,2-dihydro-3H-indazol-3-one derivative of the formula I ##STR1## wherein Ra is hydrogen, halogeno, nitro, hydroxy, (2-6C)alkanoyloxy, (1-6C)alkyl, (1-6C)alkoxy, fluoro-(1-4C)alkyl, (2-6C)alkanoyl, amino, (1-6C)alkylamino, di-[(1-4C)alkyl]amino, (2-6C)alkanoylamino or hydroxy-(1-6C)alkyl; Rb is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; and Y is a group of the formula --A.sup.1 --X--A.sup.2 --Q in which A.sup.1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene, or A.sup.1 is phenylene; X is oxy, thio, sulphinyl, sulphonyl, imino, (1-6C)alkylimino, (1-6C)alkanoylimino, iminocarbonyl or phenylene, or X is a direct link to A.sup.2 ; A.sup.2 is (1-6C)alkylene, (3-6C)alkenylene or (3-6C)alkynylene or A.sup.2 is cyclo(3-6C)alkylene or is a direct link to Q, or the group --A.sup.1 --X--A.sup.2 -- is a direct link to Q; or Y is (2-10)alkyl, (3-10C)alkenyl or (3-6C)alkynyl; and Q is aryl or heteroaryl. The invention also provides novel 1,2-dihydro-3H-indazol-3-ones, processes for their production and the use of 1,2-dihydro-3H-indazol-3-ones for the manufacture of medicaments for the treatment of various allergic and inflammatory diseases.

Therapeutic preparations containing indazole derivatives

The invention concerns a 1,2-dihydro-3H-indazol-3-one derivative of formula I ##STR1## wherein Ra is hydrogen, halogeno, hydroxy, cyano, trifluoromethyl, 1-6C)alkyl or (1-6C)alkoxy;

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Ludes, France

Pierre A Bruneau