Albert Rolland S.a.

Albert Roland S.a.

C.e.r.p.h.a. a French Society Organised Under the Laws of France

Societe Anonyme Dite Albert Rolland S.a.

Pierre A Bessin

Jacqueline Laforest

Germaine Thuillier

Jacqueline Bonnet

Jacqueline S Laforest, Nee Boutillier Du Retail

Germaine Thuillier, Nee Nachmias

Jean Eugene Thuillier

Bernard J Cariou

Jean-Pierre Labaune

Jacqueline S Laforest Nee Boutillier Du Retail

Jacqueline S Bonnet, Nee Roux

Sylviane S Mignonac

Sylviane S Mignonac, Nee Mondon

Jean-Claude Levy

2,2-Bisphenoxy-dimethyl-aminoethane to improve brain disfunction.

Novel pharmaceutical compositions improving oxygenation of the brain and

This invention relates to novel pharmaceutical compositions having immuno-suppressive activities, the active ingredient of which is a 4-aroyl N-alkyl or aryl pyrrolyl-2 carboxylic acid or a salt thereof. The pharmaceutical compositions have therapeutic utility for treating auto-immune diseases, or in the prevention of rejection of graft organs.

Pharmaceutical compositions having immuno-suppressive properties

This invention relates to compounds having the formula: ##STR1## which represents the isomer Z, the isomer E or the mixture of both stereoisomers of the oximino group and in which:

2-Methyl-2-phenoxy-propionic acid derivatives, process for their

The present invention relates to a method of lowering the concentration of plasma triglycerides of a subject in need thereof, which comprises administering an effective but non toxic amount of each isomer or a mixture thereof of compound ##STR1## or pharmaceutically acceptable addition salt of said amine formed with an acid.

Lowering the concentration of plasma triglycerides

The invention provides water-soluble salts of tienilic acid, 2,3-dichloro-4-(2-thienylcarbonyl)-phenoxyacetic acid, and amino acids of the formula ##STR1## in which n is an integer of 1 to 5 and R represents a basic nitrogenous group, preferably an amino group or guanidino group. These salts, unlike the parent acid are water-soluble and are of good biodisponibility and may be used in injectable form, e.g. for emergency treatment.

Water-soluble salts of tienilic acid

Aromatic compounds having the following formula are disclosed: ##STR1## in which, A in the heterocyclic group is selected from the group of O and S;

Thienyl or furyl phenyl O-hetero amino alkyl oximes and use thereof

The invention provides certain 4-keto-phenoxyacetic acids and their oximes of the formula: ##STR1## in which A is selected from oxygen and sulphur,

4-Keto-phenoxyacetic acids

Compounds of the general formula I ##STR1## wherein n represents 0, 1 or 2, A represents oxygen or sulphur, Z represents oxygen or hydroxyimino, X represents hydrogen, or halogen, the dotted lines represent bonds which may be unsaturated or saturated, R.sub.1 and R.sub.2 each represent hydrogen or alkyl, and R.sub.3 represents hydrogen, halogen or methyl, and R.sub.4 represents a hydrogen atom, or R.sub.3 and R.sub.4 together with the two carbon atoms to which they are attached represent benzene, and their pharmaceutically acceptable salts are useful in therapy, in particular as uricosuric agents or as diuretic and uricosuric agents.

Furoyl- and thenoyl-aryloxyalkyl carboxylic acid derivatives, their

The present invention relates to a compound selected from the compounds of the formula: ##STR1## in which: R.sup.1 is selected from hydrogen and C.sub.1-4 alkyl,

New pyrrole derivatives, process for their preparation and therapeutic

Therapeutic compositions, particularly for treating intestinal disorders, and a method of treating colopathics by administering an effective amount of the compositions are described. The compositions contain a therapeutically effective amount of at least one isomer of the oximino group of the compound having the formula: ##STR1## in which: R is selected from the group consisting of halogen atoms and lower alkoxy groups;

Ethers of 3,4-dihydro-1-benzoxepin-5-one oxime to treat intestinal

Bis (2-phenoxyalkane carboxylic acids) and their esters and salts, as well as a method for their preparation. These compounds are useful for the treatment of hyperlipemia and arteriosclerosis.

Bis(2-phenoxyalkane carboxylic acids) and derivatives thereof and their

The present invention relates to a method of treating chronic or non-chronic respiratory disorders, consisting in administering to the patient by the oral, rectal or parenteral route, a medicament for dilating the bronchi, comprising as active ingredient at least one compound of formula I or one of its pharmaceutically acceptable salts: ##STR1## in which A represents O or S, R.sub.1, R.sub.2, R.sub.3, R.sub.4 represent the hydrogen atom, an atom of halogen, an alkyl group with 1 to 4 carbon atoms or an alkoxy or alkenyloxy group,

Method of treating respiratory disorders

The invention relates to novel thienyl phenyl O-(aminoalkyl)-ketone oximes nd to novel furyl phenyl O-(aminoalkyl)-ketone oximes. These novel compounds exhibit a coronary vasodilatatory activity and may be used in the treatment of cardiopathies. The invention also relates to a process for preparing these novel compounds by reaction of a diaromatic ketone with a hydroxylamine.

Growing community of inventors

Chilly Mazarin, France

Pierre A Bessin