Carlo Erba S.p.a.

Farmitalia Carlo Erba S.p.a.

Piero Sberze

Gianfederico Doria

Maria L Corno

Francesco Lauria

Marcello Tibolla

PierNicola Giraldi

Ciriaco Romeo

Marcellino Tibolla

Pier Nicola Giraldi

Substituted pyrido [1,2-a] pyrimidines and pharmaceutical compositions containing them, suitable for use as anti-allergy, anti-ulcer, and anti-diabetic agents.

Substituted pyrido [1,2-a] pyrimidines useful as anti-allergic,

The present invention relates to substituted 2-(pyridyl-cyclopropyl)-chromones, to a process for their preparation and to pharmaceutical compositions containing them.

2-(Pyridyl-cyclopropyl)chromones

Substituted 6,7-methylen[1,2-a]pyrimidines and pharmaceutical compositions containing them, suitable for use as anti-allergic, anti-ulcer and anti-diabetic agents.

Substituted 6,7-methylene pyrido[1,2-a]pyrimidines useful as

3,4-Dihydro-quinazoline derivatives, such as 6-carboxy-2-(2'-ethoxy-phenyl)-3,4-dihydro-4-oxo-quinazoline, are disclosed. The compounds possess anti-allergy properties and can be used for the treatment of allergic conditions.

3,4-Dihydro-quinazoline derivatives

Substituted 2-cyclopropylchromones, process of preparation, pharmaceutical compositions and method of treating allergies are disclosed.

Substituted 2-cyclopropyl-chromones and pharmaceutical compositions and

3,4-Dihydro-4-oxo-quinazoline derivatives substituted in the 2-position by a substituted phenyl group are disclosed. The derivatives possess anti-allergy properties and can be used for the treatment of allergic conditions.

2-Disubstituted phenyl-3,4-dihydro-4-oxo-quinazoline derivatives and

6-CARBOXY-FLAVONE DERIVATIVES ARE DISCLOSED, WHEREIN THE FLAVONE DERIVATIVE IS SUBSTITUTED AT THE 2'-POSITION WITH AN ALKOXY GROUP, WHICH MAY BE SUBSTITUTED, AND WHEREIN THE PHENYL RING ALSO CARRIES AN ALKYL SUBSTITUENT. The flavone derivatives exhibit anti-allergic activity and spasmolytic activity.

6-Carboxy-flavone derivatives and process for their preparation

Chromone compounds carrying a pyridyl substituent at the 2-position are disclosed, such as, for instance, 6-carboxy-2-(2'-pyridyl)-chromone. The disclosed compounds are useful in the treatment of allergies.

5:6-Benzo-.gamma.-pyrone derivatives and process for their preparation

Chromone compounds carrying a pyrazinyl substituent at the 2-position are disclosed, such as, for instance, 6-carboxy-2-(2'-pyrazinyl)-chromone. The disclosed compounds are useful in the treatment of allergies.

6-Carboxy-2-(2'-pyrazinyl)-chromones and esters thereof

A pharmaceutical composition, and method of treating allergic conditions therewith, is disclosed, wherein said composition contains a 5:6-benzo-.gamma.-pyrone derivative, such as, for instance, 6-carboxy-2'-isopropoxy-flavone. The composition may be used to treat various allergic conditions, including bronchial asthma, allergic rhinitis, hay fever, urticaria and dermatosis.

Pharmaceutical composition containing 5:6-benzo-alpha-pyrone derivatives

Substituted 6-carboxy flavones are disclosed, such as, for instance, 6-carboxy-2'-isopropoxy-flavone. Such flavone derivatives possess anti-allergic activity, decrease airway resistance and increase pulmonary compliance. In addition, the compounds possess anti-ulcer activity.

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Varese, Italy

Piero Sberze