Gruppo Lepetit S.p.a.

Biosearch Italia S.p.a.

Piero Antonini

Giancarlo Lancini

Angelo Borghi

Richard J White

Raffaele Palumbo

The present invention relates to a method for selectively enhancing the production of factors A.sub.2 and/or A.sub.3 of antibiotic A/16686 either to isolate these single components or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A/16686 producing culture during fermentation.

Method for selectively increasing the ratio of single major components

The object of this invention are de-mannosylated teicoplanin derivatives which can be obtained in good yield by microbiological transformation with cultures of Nocardia orientalis NRRL 2450 or Streptomyces candidus NRRL 3218.

Process for the preparation of de-mannosyl teicoplanin derivatives

The present invention relates to new teicoplanin-like antibiotics differing from the parent compound in the length of the acyl group. The compounds of the invention are obtained according to a microbiological process and possess an antimicrobiol activity mainly against gram positive bacteria.

Teicoplanin-like derivatives

The oject of this invention are de-mannosylated teicoplanin derivatives which can be obtained in good yield by microbiological transformation with cultures of Nocardia orientalis NRRL 2450 or Streptomyces candiodus NRRL 3218.

De-mannosyl teicoplanin derivatives

Novel rifamycin compounds, designated P, Q, R and U, produced by the fermentation of mutant strains of Streptomyces mediterranei.

Rifamycin R and microorganisms useful in the production of rifamycins

This invention is directed to rifamycin compounds which are produced by fermentation of Nocardia mediterranea ATCC 31064, ATCC 31065 or ATCC 31066 in an aqueous nutrient medium under aerobic conditions. These rifamycins are referred to as rifamycin P, rifamycin Q, rifamycin R and rifamycin U.

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Arluno, Italy

Piero Antonini