Sicor Inc.

Plus Chemicals Sa

Sicor Spa

Chiron Bv

Pierluigi Rossetto

Peter Lindsay MacDonald

Ettore Bigatti

Alexandr Jegorov

Adrienne Kovacsne-Mezei

Roman Gabriel

Ales Gavenda

Dario Tentorio

Riccardo Stradi

Zvi Harel

Augusto Canavesi

Jiri Faustmann

Gaia Banfi

Peter L MacDonald

Joost J Holthuis

Provided are sorafenib hemi-tosylate, polymorphs thereof, polymorphs of sorafenib tosylate, preparation thereof and pharmaceutical compositions thereof.

Polymorphs of sorafenib tosylate and sorafenib hemi-tosylate, and processes for preparation thereof

Provided are polymorphs of fluticasone furoate and processes for preparation thereof.

Polymorphs of fluticasone furoate and process for preparation thereof

Processes useful in the preparation of pharmaceutical compounds such as fulvestrant and processes for the preparation of fulvestrant.

Process for the preparation of 7&#x3b1;-alkylated 19-norsteroids

The present invention provides processes for preparing Palonosetron salts, especially, the hydrochloride salt and intermediates used to prepare Palonosetron salts.

Processes for preparing palonosetron salts

The invention provides a high-yield process for the preparation of letrozole having a high purity, without the need for removal of the 4-[1-(1,3,4-triazolyl)methyl]benzonitrile impurity at the intermediate stage. The invention also provides a process for the synthesis of letrozole in which formation of the impurity 4-[1-(1,3,4-triazolyl)methyl]benzonitrile during the first stage is minimized. In the process, a 4-(halomethyl)benzonitrile is reacted with a salt of 1H-1,2,4-triazole, reducing the formation of the impurity. Preferably, the preparation is conducted as a one-pot process.

Process for the preparation of letrozole

Process for preparing (S) (+)-4,4'-(1-methyl-1,2-ethanediyl)-bis

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Lodi, Italy

Pierluigi Rossetto