Congenia S.r.l.

PierGiuseppe Pellicci

Stephen Martin Courtney

Christopher John Yarnold

Saverio Minucci

Paolo Bernardi

Gilles Pain

Marco Giorgio

Joachim Kraemer

The invention discloses the use of a compound of formula (I), wherein R, R, R, and Reach independently represents: hydrogen; halo; hydroxy; (C-C) alkyl optionally substituted by hydroxy or (C-C) alkoxy; (C-C) haloalkyl; (C-C) alkoxy; and (C-C) haloalkoxy; for the preparation of a medicament for the prevention and/or treatment of diseases resulting from opening of the MPTP which are characterized by degenerative tissue damages, in particular, diabetes and diabetic complications, neurological diseases and stroke, heart infarction, inherited dystrophies and hepatitis, more particularly, diabetic vascular diseases, such as diabetic retinopathy, and neurodegenerative disorders, such as multiple sclerosis. Further objects are a group of selected individual compounds of formula (I) for use as medicaments and a further group of selected individual compounds of formula (I) as novel compounds. 

Phenyl substituted maleimides as medicaments for blocking degenerative tissue damages by inhibiting MPT

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Opera, Italy

PierGiuseppe Pellicci