Bracco Imaging S.p.a.

Dibra S.p.a.

Pierfrancesco Morosini

Luciano Lattuada

Fulvio Uggeri

Silvio Aime

Pier Lucio Anelli

Kondareddiar Ramalingam

Rolf E Swenson

Carlo Scolastico

Marino Brocchetta

Christoph De Haen

Enzo Terreno

Daniela Delli Castelli

Leonardo Manzoni

Daniela Palano

Matteo Galli

Daniela Arosio

Edmund R Marinelli

Bo Song

Massimo Visigalli

Giovanni Battista Giovenzana

Roberta Fretta

Franco Fedeli

Mario Virtuani

Giovanna Lux

Luisella Calabi

Ornella Gazzotti

Giuseppe Manfredi

Silvia Ceragioli

Camilla Cavallotti

Michele Serleti

Marco Lolli

Aurelia Ferrigato

Massimo Sisti

Giovanni Palmisano

Ramalingam Kondareddiar

Vito Lorusso

Linda Chaabane

The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.

Process for the preparation of gadobenate dimeglumine complex in a solid form

The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.

Integrin targeted synthetic ligands for diagnostic and therapeutic applications

The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors.

Fibrin binding peptide conjugates for diagnostic and therapeutic applications

The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.

Contrast agents endowed with high relaxivity

The present invention relates to a novel class of paramagnetic ion-based contrast i agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic i profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity. Formula (I): A(LR)wherein: A is a linear or cyclic chelating backbone moiety; R is, independently, H or a CCaminopolyol moiety comprising a 'straight or branched alkyl chain substituted by from 2 to 30 hydroxyl groups, the said chain being optionally interrupted by one or more groups selected from -0-, &#x2014;NH&#x2014;, &#x2014;N&#x3c;, &#x2014;CO&#x2014;, &#x2014;CONH&#x2014;, &#x2014;NHCO&#x2014;, &#x2014;CON&#x3c; or &#x3e;NCO&#x2014;; and optionally substituted by one or more C4-C10 cyclic units; L is, independently, a direct bond or 'a divalent straight or branched linker moiety between A and R, at most comprising 20 carbon atoms; V is a positive integer from 1 to 7; with the proviso that at least one of the R groups is other than H; or a physiologically acceptable salt of such ligand.

Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (MRI) which contain a chelating moiety with polyhydroxylated substituents

Compounds of general formula (I): with substituents as defined herein and their chelates with bi-trivalent ions of the metal elements of atomic numbers 20 to 31, 39, 42, 43, 44, 49, and 57 to 83, and radioisotopes chosen amongPb,Ga,Ga,As,In,In,Y,Ru,Cu,Cu,Fe,Mn,La,Yb,Sm,Ho,Pm,Lu,Pr,Gd,Bi,Sc,Pm,Cu,Ag,Au,Tb,Cr,Tm,Ce,Yb,Y,Dy,Dy,Ru,Ru,Re,Tc,Bi,Bi,Bi,Rh,Pd,Sn,Sn andAu, as well as the salts thereof with physiologically compatible bases or acids.

Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy

Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.

Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics

Diagnostic imaging contrast agent with improved in serum relaxivity

Novel paramagnetic metal ion chelates and their use as contrast agents in the diagnostic technique known as 'magnetic resonance imaging' (M.R.I.) of the gastrointestinal tract and particularly of the liver, are described. The novel compounds result from the conjugation of a bile acid with a chelating agent and are capable of chelating the ions of bivalent and trivalent metals. The compounds have formula A-L-B in which A is the residue of a bile acid and derivatives of a bile acid, B is the residue of a chelating agent of a bivalent or trivalent metal ion having an atomic number of 20 to 31, 39, 42, 43, 44, 49, 57 to 83, L is a ligand between A and B.

Paramagnetic metal icon chelates and use thereof as contrast agents in

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Milan, Italy

Pierfrancesco Morosini