Gruppo Lepetit S.p.a.

Biosearch Italia S.p.a.

Pierfausto Seneci

Romeo Ciabatti

Sergio Lociuro

Adriano Malabarba

Aldo Trani

Pietro Ferrari

Ermenegildo Restelli

Jurgen K Kettenring

Basic proline-amide derivatives of GE 2270 and GE 2270-like antibiotics

Basic oxazoline-amide derivatives of GE2270 and GE2270-like antibiotics

The present invention is directed to new C.sup.63 amide derivatives of teicoplanin wherein the amide moiety is derived from a di- or poly-alkylamine, and to a process for preparing them. The derivatives are prepared by reacting a teicoplanin-like product with an active ester forming reagent such as chloroacetonitrile and then contacting said active ester with the appropriate di- or poly-alkylamine. The amide derivatives of the invention are active against gram positive and gram negative bacteria.

Substituted alkylamide derivatives of teicoplanin

The present invention is directed to a new class of teicoiplanin derivatives, a process for preparing them and their use as pharmaceutically active substances.

O.sup.56 -alkyl derivatives of aglycone and pseudo aglycones of

Growing community of inventors

Desenzano del Garda, Italy

Pierfausto Seneci