Olon S.p.a.

Antibioticos S.p.a.

Piera Fonte

Giovanni Lazzari

Walter Cabri

Jacopo Roletto

Paolo Paissoni

Sara Olmo

The present invention relates to a process for obtaining Tiacumicin B with a well defined crystal habit and particle size. The process according to the invention comprises repeating cycles of heating and cooling under controlled conditions of temperature and stirring.

Process for preparing novel forms of tiacumicin B

The present invention relates to an improved process for the purification of tiacumicin B. Specifically, the invention relates to a simplified, optimised process for the purification of tiacumicin B from a fermentation broth, using chromatography techniques. In particular, the invention relates to a method for purifying tiacumicin B which comprises subjecting a liquid containing tiacumicin B to at least one hydrophobic interaction chromatography step. The process according to the invention is simpler than the processes according to the prior art, and can easily be used on a large scale for commercial production.

Procedure for the purification of tiacumicin B

A process for the synthesis of pergolide (Formula (I)) (D-6-n-propyl-8&#x3b2;methylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without isolating most intermediates and is particularly convenient both from the yield and safety standpoint. Moreover, pergolide thereby obtained is highly pure and can be conveniently transformed into pergolide mesylate

Growing community of inventors

Turin, Italy

Piera Fonte