Farmitalia Carlo Erba

Farmitalia Carlo Erba S.r.l.

Pier P Lovisolo

Paolo Cozzi

Antonio Pillan

Leone Bertone

Piero Melloni

Paolo Salvadori

Gianfederico Doria

Nicola Mongelli

Carlo Passarotti

Ada Buttinoni

Osvaldo Magni

Romano Angelucci

Maria Bergamaschi

Alkoxy methyl pyrazine N-oxides having anti lypolytic, hypotriglyceridemic and hypocholesterolaemic properties and utility are disclosed.

Ethers of substituted hydroxymethlypyrazines

The compounds of the invention have the following general formula (I) ##STR1## wherein each of the groups R, R.sub.1 and R.sub.2, which may be the same or different, represents a hydrogen atom, a C.sub.1 -C.sub.6 alkoxy or C.sub.1 -C.sub.6 alkyl group, and R.sub.3 represents a straight or branched chain, saturated or unsaturated, C.sub.1 -C.sub.8 aliphatic hydrocarbon group. The compounds are useful as antilipolytic agents.

Ethers of substituted hydroxymethylpyrazines

The invention relates to compounds having the general formula (I) ##STR1## wherein R.sub.1 is carboxy, esterified carboxy or an amide of formula ##STR2## in which R.sub.9 is hydrogen or C.sub.1 -C.sub.6 alkyl, A is C.sub.2 -C.sub.6 alkylene and R.sub.a and R.sub.b are hydrogen or C.sub.1 -C.sub.6 alkyl or R.sub.a and R.sub.b taken together with the nitrogen atom to which they are linked form a saturated, optionally substituted, heteromonocyclic ring;

Dibenzo[b,d]thiopyran derivatives, pharmaceutical composition and use

Platelet aggregation inhibiting compositions and methods of use containing compounds of the formula ##STR1## where Z completes a bond or is a ##STR2## group; one of R.sub.1 and R.sub.2 is hydroxy and the other is hydrogen or alkyl, or R.sub.1 and R.sub.2, taken together, form an oxo group; and the remaining substituents are as defined in the specification.

N-imidazolyl derivatives of 1,2,3,4-tetrahydro-naphthalene and indan as

Compounds of the formula (1) ##STR1## wherein n is 1 or 2;

Condensed cycloaliphatic derivatives of substituted

Compounds of the formula ##STR1## where Z completes a bond or is a ##STR2## group; one of R.sub.1 and R.sub.2 is hydroxy and the other is hydrogen or alkyl, or R.sub.1 and R.sub.2, taken together, form an oxo group;

N-Imidazolyl derivatives of 1,2,3,4-tetrahydro-naphthalene and indan

The present invention relates to new 6-substituted 6H-dibenzo [b,d]pyran derivatives, to a process for their preparation and pharmaceutical and veterinary compositions containing them.

6-Substituted 6H-dibenzo[b,d]pyran derivatives and process for their

Ethers of substituted hydroxymethylpyrazines, such as, for instance, the compound 2-methoxymethyl-5-methylpyrazine-4-oxide. The compounds exhibit elevated lipid-lowering activity, especially anti-lipolytic activity (decrease of plasma-free fatty acids), triglyceride-lowering activity, cholesterol-lowering activity, and plasma-phospholipid-lowering activity.

3-(1-imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran, such as, for instance, the compound 3-(1-imidazolyl)-2,3-dihydro-4H-1-benzopyran-4-one, are disclosed, as well as method of making same, and pharmaceutical compositions containing same. Also disclosed is a method of using such compounds to inhibit blood platelet aggregation, to increase total serum HDL cholesterol, to increase the ratio between .alpha.-lipoprotein and .beta.-lipoprotein total cholesterol, and/or of reducing total serum cholesterol or serum triglycerides.

3-(1-Imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran

2-Hydroxymethyl-pyrazine derivatives are disclosed, such as, for instance, the compound 2-hydroxymethyl-5-methylpyrazine-4-oxide. The compounds exhibit an elevated lipid lowering activity, and can be used to control triglyceride and cholesterol levels.

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Milan, Italy

Pier P Lovisolo