Bracco Imaging S.p.a.

Dibra S.p.a.

Bracco International Bv

Bracco S.p.a.

Pier Lucio Anelli

Fulvio Uggeri

Marino Brocchetta

Luciano Lattuada

Mario Virtuani

Giovanna Lux

Massimo Visigalli

Enrico Cappelletti

Roberta Fretta

Franco Fedeli

Pierfrancesco Morosini

Marcella Murru

Christoph De Haen

Giuseppe Manfredi

Andrea Beltrami

Ornella Gazzotti

Michele Serleti

Maria Argese

Valeria Boi

Sonia Gazzetto

Laura Galimberti

Herv&eacute; Tournier

Fulvia Vella

Livio Cavalieri

Daniela Palano

Marco Lolli

Roberta Mazzon

Milena Gabellini

Chiara Gallotti

Kondareddiar Ramalingam

Alessandro Maiocchi

Carlo Felice Viscardi

Ramachandran S Ranganathan

Ernst Felder

Giovanni Battista Giovenzana

Federico Maisano

Alfonso Nardelli

Pietro Delogu

Luisella Calabi

Silvia Ceragioli

Giovanni Rivolta

Maurizio Franzini

Aurelia Ferrigato

Mauro Citterio

Marco Leonardi

Armando Mortillaro

Andrea Romeo

Cristina Neira

Paolo Morosi

Fabrizio Goffredi

Alberto Candotti

Pier Francesco Morosini

Livio Cavaliere

Hervé Tournier

The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.

Preparation of a solid form of gadobenate dimeglumine

A solution is proposed for closing a mouth () of a container () of a liquid (). A corresponding closure () comprises a cap () having fixing means () for fixing the cap () to the container (), a delivery port () for delivering the liquid () from the container (), a valve member () in a closed position wherein the valve member () closes the delivery port (), a cap suction conduit () for suctioning air into the container () during the delivering of the liquid () and a connector () for connecting to a delivery device () of the liquid (), the connector () being in fluid communication with the delivery port (), a slider () slidebly coupled with the cap (), the slider () having a slider suction conduit () for suctioning the air into the container () during the delivering of the liquid () slidebly coupled with the cap suction conduit (), and a frangible element () closing the cap suction conduit () or the slider suction conduit (), wherein the closure () is configured to cause the delivery device () during the connecting thereof to move inwards the container (), in a fixed condition wherein the closure () is fixed to the container (), and thus moving the valve member () inwards the container to an open position, wherein the valve member () opens the delivery port (), and moving the slider () inwards the container to break the frangible element (), thereby putting in fluid communication the slider suction conduit () with the cap suction conduit ().

Container closure operated by a connecting device

The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.

Process for the preparation of a sulfated derivative of 3,5-diiodo-o-[3-iodophenyl]-l-tyrosine

The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chloro-sulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.

Process for the preparation of a sulfated derivative of 3,5-diiodo-O-[3-iodophenyl]-L-tyrosine

The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.

Process for the preparation of gadobenate dimeglumine complex in a solid form

The present invention relates to a finger-grip device designed to be placed on the flange of a cylindrical barrel of a medical syringe or cartridge, increasing the contact surface with the fingers of the operator during the injection or withdrawal of fluids to or from a patient, characterised in that it does not stop or hinder the run of the plunger within the cylindrical barrel.

Finger-grip device for medical syringe or cartridge

The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.

Process for the preparation of a iodinating agent

The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available &#x3b1;-hydroxyacid or a salt thereof.

Process for the preparation of triiodinated carboxylic aromatic derivatives

The present invention relates to a process for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution of this latter with an anion exchanger solid phase.

Process for the preparation of contrast agents

A process for the preparation of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxo-propyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide (iopamidol) starting from 5-amino-N,N&#x2032;-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide (II) which process comprises a) reacting the compound of formula (II) with a suitable protecting agent, to give a compound of formula (III) wherein R is a group of formula A or B wherein Ris a hydrogen atom, a C&#xf7;Cstraight or branched alkoxy group, Ris hydrogen, a C&#xf7;Cstraight or branched alkoy group and R3 ?is a C&#xf7;Cstraight or branched alkyl group, a trifuoromethyl or a trichloromethyl group; b) acylating the amino group in position 5 of the intermediate compound of formula (III), by reaction with a (S)-2-(acetyloxy)propanoyl chloride to give a compound of formula (IV) wherein R is as defined above; and c) removing all the acyl groups present in the compound of formula (IV) under basic conditions, with prior cleavage of the cyclic protections of the hydroxy groups in the carboxamido substituents under acidic conditions, when R is a group of formula A carboxamido hydroxy groups under acidic conditions. The invention also refers to the new intermediates of formula (III) and (IV) wherein &#x2014;R is a group A.

Process for the preparation of iopamidol and the new intermediates therein

The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid of formula (V), wherein Rrepresents a straight or branched (C-C)-alkyl group, with at least the stoichiometric amount of an amine of formula HNR.

Process for the preparation of N,N-substituted 5-amino-1,3-benzenedicarboxamides

A process for the preparation of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxo-propyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide (iopamidol) starting from 5-amino-N,N&#x2032;-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide (II) which process comprises a) reacting the compound of formula (II) with a suitable protecting agent, to give a compound of formula (III) wherein R is a group of formula A or B wherein Ris a hydrogen atom, a C&#xf7;Cstraight or branched alkoxy group, Ris hydrogen, a C&#xf7;Cstraight or branched alkoxy group and R3 ?is a C&#xf7;Cstraight or branched alkyl group, a trifuoromethyl or a trichloromethyl group; b) acylating the amino group in position 5 of the intermediate compound of formula (III), by reaction with a (S)-2-(acetyloxy)propanoyl chloride to give a compound of formula (IV) wherein R is as defined above; and c) removing all the acyl groups present in the compound of formula (IV) under basic conditions, with prior cleavage of the cyclic protections of the hydroxy groups in the carboxamido substituents under acidic conditions, when R is a group of formula A carboxamido hydroxy groups under acidic conditions. The invention also refers to the new intermediates of formula (III) and (IV) wherein &#x2014;R is a group A.

Process for the preparation of iopamidol and the new intermediated therein

Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI) The paramagnetic complexes of the polycarboxylic ligands possess advantageous tensioactive properties and are useful as MRI contrast media in formulations for investigating the blood pool.

Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents

Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with these metal ions and physiologically compatible salts thereof and therein magnetic resonance imaging.

Chelating compounds, their complexes with paramagnetic metals

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Milan, Italy

Pier Lucio Anelli