Other

National Taiwan University

Pi-Hui Liang

Chun-Kai Chang

Pei-Fang Chiu

Yen-Hsun Lai

Chee-Wai Chaw

The present disclosure provides a novel conjugate or a pharmaceutically acceptable salt thereof, wherein the conjugate has an active pharmaceutical moiety or a prodrug thereof, a targeting module and a linker therebetween. The conjugate or a pharmaceutically acceptable salt thereof is useful for treating a disease, recurrence or progression in a subject or increasing the likelihood of survival over a relevant period in a subject diagnosed with a disease.

Conjugate for targeting therapy

The present invention is directed to novel chemical compounds in which a lipophilic moiety such as a lipid, fatty acid, polyethylene glycol or terpene is covalently attached to a non-acylated or desacylated triterpene saponin via a carboxyl group present on the 3-O-glucuronic acid of the triterpene saponin. The attachment of a lipophile moiety to the 3-O-glucuronic acid of a saponin such asdesacylsaponin, lucyoside P, or saponin fromandenhances their adjuvant effects on humoral and cell mediated immunity. Additionally, the attachment of a lipophile moiety to the 3-O-glucuronic acid residue of non- or des-acylsaponin yields a saponin analog that is easier to purify, less toxic, chemically more stable, and possesses equal or better adjuvant properties than the original saponin.

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Taipei, Taiwan

Pi-Hui Liang