University of Minnesota

Photini-Effie C Tsilibary

Leo T Furcht

James B McCarthy

Aristidis S Charonis

Suman Setty

Michael Mauer

Mary K Chelberg

Analysis of alterations in integrin subunit expression, particularly &agr;1 and/or &agr;2 integrin subunit expression from integrin producing cells as compared to normal controls as a diagnostic method to identify individuals who have or are predisposed to pathologies associated with altered matrix deposition, such as diabetic renal nephropathy.

Analysis of alpha integrins for the diagnosis of diabetic nephropathy

A polypeptide having the following formula is provided: gly-glu-phe-tyr-phe-asp-leu-arg-leu-lys-gly-asp-lys which can bind heparin and promote cellular adhesion. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with a composition including the polypeptide are also provided.

Prosthetic devices coated with a polypeptide with type IV collagen

A polypeptide having the following formula is provided: gly-val-lys-gly-asp-lys-gly-asn-pro-gly-trp-pro-gly-ala-pro which has the ability to promote cellular adhesion, spreading the motility, while remaining highly cell specific. Medical applications such as chemodiagnostic and chemotherapeutic devices are also provided.

Polypeptide with type IV collagen cell adhesion, spreading and motility

A polypeptide having the following formula is provided: leu-ala-gly-ser-cys-leu-ala-arg-phe-ser-thr-met which can bind heparin and promote cellular adhesion. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with a composition including the polypeptide are also provided.

Growing community of inventors

Minneapolis, MN, United States of America

Photini-Effie C Tsilibary