Pfizer Corporation

Cystic Fibrosis Foundation Therapeutics, Inc.

Phoebe Chiang

Willard M Welch, Jr

William A Novomisle

Shomir Ghosh

Angel Guzman-Perez

Ravi Shanker Garigipati

Paul Andrew Dasilva-Jardine

Kevin K Liu

Disclosed herein are pyrimidinyl compounds that are contemplated to be modulators of cystic fibrosis transmembrane regulators (CFTR), and methods of making and using same. Also provided are pharmaceutical compositions and methods of treating disorders associated with cystic fibrosis transmembrane regulators, such as airway inflammation, cystic fibrosis, and the like.

Pyrimidine compounds and methods of making and using same

Compounds of Formula (IC) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HTreceptors in animals are described herein.

5-HT receptor ligands and uses thereof

Compounds of Formula (IA) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HTreceptors in animals are described herein

Compounds of Formula (IA) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT receptors in animals are described herein.

Growing community of inventors

East Lyme, CT, United States of America

Phoebe Chiang