Visby Medical, Inc.

Phoebe Cao

David Swenson

Jesus Ching

Victor Briones

Gregory Loney

Adam De La Zerda

Keith Edward Moravick

Colin Kelly

Boris Andreyev

Brian Ciopyk

Helen Huang

Shaunak Roy

Jonathan Hong

Teresa Abraham

Adrienne C Lam

Valeria Revilla

Gary Schoolnik

Bryan D Knysh

Rajinder K Bhatia

Danielle McSheery

The disclosure relates generally to molecular diagnostic devices configured to amplifying a single nucleotide polymorphism (SNP) locus and discriminate between two or more allelic variants of the SNP, indicating presence or absence of a target allele. In some embodiments, the molecular diagnostic devices are capable of detecting, at point-of-care, SNPs associated with resistance or susceptibility to antibiotic treatment of bacterial infections. In other aspects, the disclosure provides methods of treatment for disease or disorders (e.g. bacterial infections) where treatment is guided by presence or absence of an allele at a SNP locus as determined by such molecular diagnostic devices.

Devices and methods for antibiotic susceptibility testing

A method includes conveying a detection solution containing a target amplicon into a detection module of a molecular diagnostic test device. The detection module includes a detection surface including a series of capture probes to which a first portion of the target amplicon is bound when the detection solution is conveyed. A first reagent formulated to produce a visible signal indicating a presence of the target amplicon is then conveyed into the detection module. The first reagent is bound to a second portion of the target amplicon when the first reagent is conveyed. A second reagent is conveyed into the detection module. The second reagent includes a precipitating substrate formulated to catalyze the production of the visible signal by producing an insoluble colored product when the second reagent is in contact with the first reagent. The method includes viewing the visible signal via a transparent portion of the detection module.

Devices and methods for the detection of molecules using a flow cell

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San Jose, CA, United States of America

Phoebe Cao