Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-hopitaux De Paris

Institut Pasteur

Institute Pasteur

Phillippe Mauclere

Francoise Barre-Sinoussi

Ibtissam Loussert-Ajaka

Sentob Saragosti

Francois Simon

Retroviral strains of the non-M, non-O HIV-1 group, in particular a strain designated YBF30, its fragments and also its uses as a diagnostic reagent and as an immunogenic agent. The HIV-1 viruses which differ both from the M group and the O group exhibit the following characteristics:

Non-M, non-O HIV-1 strains, fragments and uses

Retroviral strains of the non-M, non-O HIV-1 group, in particular a strain designated YBE30, its fragments and also its uses as a diagnostic reagent and as an immunogenic agent. The HIV-1 viruses which differ both from the M group and the O group exhibit the following characteristics:

The invention provides peptides which are expressed by the env gene of a non-M, non-O HIV-1 virus, in particular a strain designated YBF30. The invention also provides fragments of the peptides that including the V3 loop region and their corresponding nucleotide sequences. The invention further provides kits including diagnostic reagents containing these molecules or immunogenic compositions containing these peptides, as well as methods for screening and typing non-M, non-O HIV-1 viruses and HIV-1 viruses expressing these peptide and/or nucleotide sequences.

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Bordeaux, France

Phillippe Mauclere