William Marsh Rice University

Phillipp Klahn

Kyriacos Costa Nicolaou

Debashis Mandal

Dionisios Vourloumis

Rohan Diliprao Erande

Jun Yin

In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R, R, R, R, X, X, X, and Aare as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. 

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Munster, Germany

Phillipp Klahn