Midatech Limited

Monosol Rx, LLC

Aquestive Therapeutics, Inc.

Midatech Pharma Limited

Phillip Williams

Thomas William Rademacher

Alexander Mark Schobel

Eric Dadey

Africa Garcia Barrientos

Garry L Myers

Daniel Palmer

Jan Mous

Tom Coulter

Keith Joseph Kendall

Esther De Torres Dominguez

Meike Roskamp

Jon Golding

Rhian Groves

Justin N W Barry

Christof Bachmann

Javier Del Campo Menoyo

Javier Del Menoyo

Ester De Dominguez

Justin Nw Barry

Ester De Torres Dominguez

The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject. Also disclosed are methods of treatment by administering the nanoparticles alone or in combination with radiotherapy.

Nanoparticles and their use in cancer therapy

The present invention provides nanoparticles and compositions comprising such nanoparticles, as well as methods for intracellular delivery of peptides, and methods of producing nanoparticles and related products. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises a peptide of choice that is covalently linked to the core via a second linker. The second linker comprises a peptide portion and a non-peptide portion, wherein said peptide portion of said second linker comprises the sequence XXZ, wherein: Xis an amino acid selected from A and G; Xis an amino acid selected from A and G; and Zis an amino acid selected from Y and F.

Nanoparticle-peptide compositions

Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.

Combination peptide-nanoparticles and delivery systems incorporating same

The present invention relates to insulin- and insulin analog-carrying nanoparticles formulated together with or for use with free insulin or with an insulin analog, such as a rapidly-acting insulin analog. The compositions of the present invention find use in medicine, particularly in glycemic control, e.g. for controlling blood glucose levels in diabetic subjects. Nanoparticle compositions of the invention, formulated together with or for use with free insulin or with an insulin analog, comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one carbohydrate moiety; and at least one insulin peptide and/or insulin analog peptide that is non-covalently bound to the corona.

Nanoparticle-insulin and insulin analogue compositions

The present invention relates to amylin peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of blood glucose regulation. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise glutathione; and at least one amylin peptide that is non-covalently bound to the corona.

Nanoparticle peptide compositions

A therapeutic or bioeffecting film delivery system which includes nanoparticles having actives bound to or associated with the nanoparticles and which when administered allow the active to perform a therapeutic or bioeffecting function.

Nanoparticle film delivery systems

Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises a core including metal and/or semiconductor atoms, wherein the core is covalently linked to a plurality of ligands, the ligands including a carbohydrate residue capable of stimulating an innate immune response, a T cell helper peptide and a danger signal. This platform may then be adapted by including one or more further ligands capable of producing a specific response to a target infectious agent.

Nanoparticles for providing immune responses against infectious agents

Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein peptides are bound to or associated with the nanoparticles.

Peptide-carrying nanoparticles

Growing community of inventors

Oxfordshire, United Kingdom

Phillip Williams