University of Massachusetts

Advanced Bioscience Laboratories, Inc.

Phillip Markham

Shan Lu

Ranajit Pal

Shixia Wang

Vaniambadi Kalyanaraman

Stephen Whitney

Tim Keen

Balachandran Nair

Stephen Charles Whitney

V S Kalyanaraman

Balachandran C Nair

Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV is disclosed. The composition and methods described herein are for the use of a DNA composition that encodes one or more different HIV envelope glycoproteins. The DNA composition can encode an HIV Gag protein. The DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV protein compositions for inducing an immune response against HIV are disclosed. Methods fro using the protein compositions as boosts following administration of the DNA compositions are provided.

Polyvalent, primary HIV-1 glycoprotein DNA vaccines and vaccination methods

Growing community of inventors

Mount Airy, MD, United States of America

Phillip Markham