University of Illinois

Phillip Lazzara

Terry D Moore

Atul D Jain

Brian J David

Benjamin Richardson

Disclosed herein are compounds that can act as inhibitors of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 ('KEAP1/NRF2') protein-protein interaction, and methods of using the compounds to treat and prevent diseases and disorders, such as COPD, multiple sclerosis, and diabetes, and in the promotion of wound healing. The compounds described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: formula (I), wherein the substituents are as described. 

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Chicago, IL, United States of America

Phillip Lazzara