Covidien LP

Confluent Surgical, Inc.

Phillip Blaskovich

Rachit Ohri

Joshua Kennedy

Valentino Tramontano

Sajida Farooqi

Lan Pham

Steven L Bennett

Daniel S Costa

Arthur Driscoll

Clifford J Herman

Olga Cherniavsky

William H Nau, Jr

Francesca Rossetto

Les Hull

Allison Waller

Stephen H Wu

Rupal Ayer

Wenxing Huang

Paul DiCarlo

Harold M Martins

Min-Shyan Sheu

Jiagui Li

Qinlin Gu

Derek Rissman

Gary R Strichartz

Christopher M Henry

Mantao Xu

Xingyan Lu

Paul Dicarlo

Gary A Nichols

Petra Brockfeld

Valentino J Tramontano

A method of treatment includes agitating a thixotropic oxidized cellulose solution; administering the agitated thixotropic oxidized cellulose solution to a target tissue site; and allowing the agitated thixotropic oxidized cellulose solution to gel at the target tissue site.

Thixotropic oxidized cellulose solutions and medical applications thereof

A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.

Oxidized cellulose microspheres

A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.

Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations

A process for dissolving modified cellulose is disclosed. The process includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose.

Dissolution of oxidized cellulose

A process for dissolving modified cellulose includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose. The dissolved modified cellulose is used to form at least one of a predictably degrading coating, film, or a fiber.

Medical devices based on oxidized cellulose

A microsphere and method for forming the same are disclosed. The microsphere includes modified cellulose and at least one of a visualization agent, a magnetic material, or a radioactive material.

Multi-encapsulated formulations made with oxidized cellulose

A microsphere is claimed which includes at least one biodegradable polymer and at least one local anesthetic, wherein about 75% of the at least one local anesthetic is released by about 72 hours and from about 80% to about 90% of the at least one local anesthetic is released by about 120 hours, thereby relieving chronic pain for at least 28 days.

Drug loaded microspheres for post-operative chronic pain

A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.

Resorbable oxidized cellulose embolization microspheres

A drug-delivery cannula assembly includes a cannula housing adapted for receiving at least one obturator shaft of an obturator assembly therethrough, one or more cannulae, and a supply line coupled to the cannula housing. The cannula housing is adapted for receiving one or more obturator shafts of an obturator assembly therethrough. The one or more cannulae define a longitudinal axis and a passageway aligned with the longitudinal axis. The one or more cannulae each include a proximal end coupled to the cannula housing. The cannula housing is configured to fluidly-couple the one or more cannulae to a source of a drug delivery supply for supplying drugs via the supply line to the one or more cannulae.

Drug-delivery cannula assembly

A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting an oxidized cellulose embolization solution into a lumen of a blood vessel to form an embolism within the lumen. The oxidized cellulose is present in an amount from about 10 % by weight to 20 % by weight of the oxidized cellulose embolization solution. The method also includes adjusting recanalization time of the embolism, which may be adjusted by tailoring a degradation rate of the oxidized cellulose.

Resorbable oxidized cellulose embolization solution

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Salem, MA, United States of America

Phillip Blaskovich