Avent, Inc.

Kimberly-clark Worldwide, Inc.

O&m Halyard, Inc.

Avent Investment, LLC

Phillip A Schorr

Eric Anthony Schepis

Ryan Caldwell

Amol Soin

David M Page

Shyamy R Sastry

Natalia Alexeeva

Roger Bradshaw Quincy, Iii

Alison Salyer Bagwell

Michael David Powers

Leah M Roldan

Joshua D White

David William Koenig

Lee Kirby Jameson

Andrew Thomas Baker

Varunesh Sharma

Hue Scott Snowden

Kok-Ming Tai

Shyamant Ramana Sastry

Emily A Reichart

Jennifer S Stadelman

Wanzhan Liu

Sara Kebede

Eric A Schepis

John Gavin Macdonald

John Gavin MacDonald

Ali Yahiaoui

Ramanathan S Lalgudi

Roger Dillard Massengale

Sridhar Ranganathan

John Anthony Rotella

Kelly Dean Branham

Alice Susan Gordon

Anthony Stephen Spencer

Sylvia Bandy Little

Brian Joseph Cuevas

Eric Clayton Steindorf

Shawn Ray Feaster

Douglas Robert Hoffman

Tyler West Crone

Thomas Gregory Estes

Michael P Mathis

Ilona F Weart

Steven R Stopper

Andrew Sweeney

Glynis Allicia Walton

Molly K Smith

Christopher Dale Fenwick

Stephanie Kute

Patricia A Stern

Gavin H Mannion

Joseph DiPietro

Aaron D Smith

Craig F Steinman

Jalpa Shah

Jeremy D Ollerenshaw

Uyles Woodrow Bowen, Jr

Jeremy Ollerenshaw

Mark R Ellswood

Aaron Drake Smith

James M Takeuchi

Allen James Dohnalik

Dwayne J-k Jackson

Sean P Gorman

Angela Dobson

Elliot Blake Bourgeois

Skyler Canute

David T Curd

Anthony Steve Spencer

Leah Roldan

Jacob J Fantuz

Todd Hanson

David James McNamara

Chris Zobkiw

Gleb Klimovitch

Stefan L Blum

Angela G Dobson

Roger D Massengale

Joseph Dipietro

Shyamant R Sastry

Dwayne J-K Jackson

Roger Bradshaw Quincy Iii

Thomas G Estes

Kelly D Arehart

Susan G Oslund

Uyles Woodrow Bowen

Lisa A Linton

Daniel Oster

The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting pain while preserving other sensory and motor function, and proprioception.

Device and method to selectively and reversibly modulate a nervous system structure to inhibit pain

A system and method for locating a target nerve associated with a facet joint via nerve stimulation and monitoring of electrical muscle activity in a multifidus muscle adjacent the target nerve are described. The system includes a probe housed within a cannula and comprising a probe electrode; a recording electrode for monitoring electrical muscle activity in a medial fascicle of the multifidus muscle; a signal generator; and a controller coupled to the probe electrode and recording electrode. The controller delivers a nerve stimulation from the signal generator to the nerve via the probe electrode and monitors electrical muscle activity in the medial fascicle via the recording electrode. The probe's proximity to the nerve is determined by the electrical muscle activity in the medial fascicle elicited as a result of the nerve stimulation, where the controller provides feedback to a user to guide placement of the probe adjacent the nerve.

EMG guidance for probe placement, nearby tissue preservation, and lesion confirmation

A method for identifying and treating a neural pathway associated with chronic pain via nerve stimulation and brain wave monitoring of a mammalian brain is described. The method includes positioning a probe to stimulate a target nerve, wherein the target nerve is suspected of being a source of chronic pain; delivering a first nerve stimulation from the probe to the target nerve, wherein the first nerve stimulation is sufficient to elicit a chronic pain response in the brain; and monitoring for evoked potential activity in the brain as a result of the first nerve stimulation. The method can also include delivering second and third nerve stimulations to confirm the correct identification of the neural pathway and to treat the chronic pain, respectively. A system and apparatus for performing a procedure to identify and treat a nerve that is the source of chronic pain are also described.

Method and system for identification of source of chronic pain and treatment

The present disclosure is directed to a portable system and method for modulating targeted neural and non-neural tissue of a nervous system to block nerve conduction for the treatment of pain. A high-efficiency portable electrical stimulation system is provided that allows a user to carry the system and move around freely while continuously receiving therapy. The electronic control system is configured to deliver high-frequency electrical stimulation at a therapeutic level, for an intended duration (e.g., up to 24 hours or more) at a manageable and/or comfortable weight for a person, to the target nerve.

Portable electrical stimulation system and method

A system for selectively blocking nerve fiber activity in a target nerve is provided. The system includes one or more electrodes. The system further includes an electronic control system electrically attached to each electrode to deliver electrical stimulation to a target nerve to block nerve signal transmission of C-fibers in the target nerve such that the nerve signal transmission of A-fibers in the target nerve providing motor function and/or low-threshold sensory function is not blocked. A method of delivering electrical stimulation to selectively block nerve fiber activity in a target nerve and a kit for performing a procedure to selectively block nerve fiber activity are disclosed.

Selective nerve fiber block method and system

An electrosurgical device is provided that includes a probe extending in a longitudinal direction and having a proximal region and a distal region. An inner diameter of the probe defines a lumen. The probe has an electrically insulated portion extending from the proximal region to the distal region and an electrically exposed conductive portion located at the distal region. The electrically exposed conductive portion delivers radiofrequency energy to an area of tissue adjacent the distal region. The device also includes a heat transfer system for removing thermal energy from the area of tissue that is in thermal contact with the area of tissue. The heat transfer system removes from about 0.1 Watts to about 50 Watts of energy from the tissue. In addition, the heat transfer system can sufficiently draw heat away from the tissue without the use of a peristaltic pump for circulating a liquid inside the lumen.

Cooled RF probes

The exemplified systems and methods facilitate a nerve conduction block at a target nerve using electrical stimulation applied from one or more electrodes located on a percutaneous lead that are placed in parallel, or substantially in parallel, and without direct contact, to a long axis of the peripheral nerve over an overlapping nerve region of greater than about 3 millimeters. The exemplified system and method can be further configured to block nerve condition without eliciting onset activity and co-excitation of non-targeted structures. The exemplified method and system can be performed using conventional percutaneous leads, though an improved percutaneous lead design is disclosed herein. In an aspect, an introducer is disclosed that facilitates accurate and consistent insertion of the percutaneous lead to the specified or intended position relative to the target nerve. In another aspect, a treatment kit comprising the various system components to treat pain is disclosed.

Percutaneous lead placement assembly

A product and method for reducing tensile strength loss associated with sterilization of the product by ionizing radiation sterilization methods is provided. The method includes providing a package that includes a layer having an oxygen transmission rate equal to or less than about 10 cubic centimeters of oxygen per 100 inches squared per 24 hours; providing a product in the package's interior; applying a vacuum to the exterior of the package in a controlled atmosphere until a vacuum pressure equal to or less than about 250 millibars is achieved; flushing the interior of the package with an inert gas until an inert gas flush pressure equal to or less than about 750 millibars is achieved; sealing the package; releasing the vacuum applied in the controlled atmosphere; and sterilizing the package/product with radiation. The resulting product has a reduction in its tensile strength of less than about 18.5% after sterilization.

Film to film packaging solution for sterilized nonwoven fabric products

Treatment kit to percutaneously block painful sensations hosted by a peripheral nerve

System and method to percutaneously block painful sensations

A method for identifying and treating a neural pathway associated with chronic pain via nerve stimulation and brain wave monitoring of a mammalian brain includes positioning a probe to stimulate a target nerve, wherein the target nerve is suspected of being a source of chronic pain; delivering a first nerve stimulation from the probe to the target nerve, wherein the first nerve stimulation is sufficient to elicit a chronic pain response in the brain; and monitoring for evoked potential activity in the brain as a result of the first nerve stimulation. The method can also include delivering second and third nerve stimulations to confirm the correct identification of the neural pathway and to treat the chronic pain, respectively. A system and apparatus for performing a procedure to identify and treat a nerve that is the source of chronic pain are also described.

Growing community of inventors

Alpharetta, GA, United States of America

Phillip A Schorr