Basf Aktiengesellschaft

International Flavors & Fragrances Inc.

Phillip A Rossy

Josef Gries

Marco Thyes

Horst Koenig

Hans D Lehmann

Werner Hoffmann

Dieter Lenke

Albrecht Franke

Kevin P Miller

Marvin Schulman

Alan Owen Pittet

Paul L Bolen

Regina D Hawn

Richard H Davidson

Ira T Warder

Bruno Wuerzer

Gerhard Hamprecht

Rolf-Dieter Acker

Ludwig Friedrich

Norbert Mueller

Martin Traut

Karl-Heinz Geiss

Described are flavored calcium supplement compositions, beverage (e.g., coffee, milk, cocoa and citrus/whey protein), foodstuff, chewing gum and oral care (e.g., toothpaste and mouthwash) compositions and articles comprising flavored calcium supplements, foodstuff, beverage, chewing gum and oral care base compositions and intimately admixed therewith an aroma or taste augmenting, enhancing or imparting quantity and concentration of one or more freeze-dried or spray-dried tastand compositions containing tastands produced from,leaves (sugarcane leaves) by means of carrying out one or more physical separation unit operations on a plurality of such leaves, macerates thereof or mixtures of leaves and macerates thereof whereby one or more natural food additives, chewing gum additives or oral care additives is separated and isolated from the remainder of the plurality of leaves, macerates thereof or mixtures of leaves end macerates thereof. Such unit operations include pressurization using hydraulic press means, steam distillation, fractional distillation, supercritical carbon dioxide extraction, volatile solvent extraction and/or charcoal column separation means.

Use of spray-dried and freeze-dried sugarcane leaf essence

Use of spray-dried and freeze-dried sugarcane leaf essence in improving taste of flavored calcium supplements, foodstuffs, beverages, chewing gum, oral care compositions and calcium supplement

2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula ##STR1## where m, n, R, R.sup.1, R.sup.2 and R.sup.3 have the stated meanings, are used for the treatment of cardiac insufficiency.

2-aryl-3,4-diazabicyclo(4.n.O)alk-2-en-5-ones for the preparation of an

Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described and inhibiting thrombocyte aggregation and gastric secretion. The compounds are useful for treating disorders.

6-(acylaminoaryl)-3(2H)-pyridazinone derivatives and their use

6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R is hydrogen, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, or R and R.sup.1 together are methylene, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl, and A is hydroxyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.7 -acyloxy, a C.sub.2 -C.sub.7 -carbamic acid ester group, C.sub.1 -C.sub.6 -alkylsulfonyloxy, C.sub.1 -C.sub.6 -alkylmercapto, carboxyl, C.sub.2 -C.sub.7 -alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.

6-Aryl-4,5-dihydro-3(2H)-pyridazinones, and their use as

2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I ##STR1## where m and n are identical or different and each is 1, 2 or 3, and R, R.sup.1 and R.sup.2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones, and compositions for

Dihydrothiophenecarboxylates of the formula ##STR1## where R.sup.1 and R.sup.2 have the meanings given in the description, are used for controlling undesirable plant growth.

Dihydrothiophenecarboxylates and their use for controlling undersirable

New thiophene compounds and a new process for the manufacture of thiophene compounds by dehydrogenating dihydrothiophene with certain halogen compounds. The products are starting materials for the manufacture of pharmaceuticals, dyes and plant protection agents and, in particular, for the manufacture of additives to foodstuffs, feeds, beverages and pharmaceuticals.

Thiophene compounds and their manufacture

3-Halosulfonylthiophene-carboxylic acid compounds are manufactured by reacting 3-ketothiophane-carboxylic acid compounds with sulfonic acid compounds, reacting the end product from the 1st reaction stage with alkali metal polysulfides, reacting the end product from the 2nd stage with a dehydrogenating agent and finally reacting the end product from the 3rd stage with halogen and water. The products are starting compounds for the manufacture of drugs, dyes and crop protection agents and have an anti-inflammatory, analgesic and anti-rheumatic action. In particular, the end products I are starting materials for the manufacture of sweeteners which are non-toxic and free from an after-taste, flavor-improving agents, diabetic aids and feedstuffs, and provide the means of a simple and economical synthesis of thiophene-saccharins.

Manufacture of 3-halosulfonylthiophene-carboxylic acid compounds

Growing community of inventors

Ludwigshafen, Germany

Phillip A Rossy