Maxygen, Inc.

Pioneer Hi-bred International, Inc.

Verdia Inc.

Codexis Mayflower Holdings, LLC

E.i. Dupont De Nemours and Company

E. I. Du Pont De Nemours

Roche Palo Alto LLC

Pioneer Hi-bred Int'l Inc.

Codexis, Inc.

E. I. Du Pont Nemours and Co.

Achaogen, Inc.

Maxyag, Inc.

Codexis Mayflower Holding, LLC

Phillip A Patten

Jeremy S Minshull

Willem P C Stemmer

Linda A Castle

Lorraine Joan Giver

Claes Gustafsson

Matthew B Tobin

Rebecca Lynne Gorton

Jon Edward Ness

Nicholas B Duck

Steven Henry Bass

Yong Hong Chen

Dan Siehl

Torben Lauesgaard Nissen

Cristina Ivy

Sridhar Viswanathan

Mark D Welch

Sridhar Govindarajan

Andreas Crameri

Billy Fred McCutchen

Takashi Yamamoto

Jingtong Hou

Roger Kemble

Daniel Siehl

Sergey A Selifonov

Zhenglin Hou

Ruth Cong

Anthony Cox

Stephen Del Cardayre

Robin A Emig

Claus M Krebber

Stefan Seeber

Stephan Fischer

Ralf Schumacher

Joseph A Affholter

S Christopher Davis

Venkiteswatan Mani Subramanian

Anne Vogt

Harald Kropshofer

Teddy Chen

Richard John Fox

Andreas Schaubmar

Stephen DelCardayre

Ajoy K Roy

Gjalt W Huisman

Lu Liu

Genhai Zhu

Carol A Hendrick

Hans Koll

William P C Stemmer

Yuxia Dong

Stephen delCardayre

Ying-Xin Zhang

Ling Yuan

Christina Ivy

Volker Heinrichs

Steve Bass

Michael W Lassner

Eric J Schepers

Nasser Yalpani

Jennifer Kara Barry

Ute Schellenberger

Weiping Xie

James J English

Yumin Tao

Ericka Bermudez

Jun-Zhi Wei

Andrew Duncan Satterfield

Daniel J Altier

Xiaohong Zhong

Barbara Rosen

Ingrid Udranszky

David Charles Cerf

Sun Ai Raillard

Jarred Kenneth Oral

Michael Freeman

Willem Pc Stemmer

Venkiteswaran Subramanian

Henrik Albert

Jianzhou Zhao

Stanley Goldman

Emily Ng

Pascal Longchamp

Bumshik Robert Pak

Kathleen Marie Harding

Stephen W Kaldor

Andrew Mark Cigan

Joshua K Young

Roberto Falkenstein

Stephane J Jenne

Stephan Jenne

Adelbert Grossmann

Heinz Ernst Moser

Madan M Paidhungat

Friederike Hesse

Qing Lu

Jian Lu

Simon Christopher Davis

Brian D Patterson

Ramesh Annasaheb Kasar

Systems and methods for sorting and imaging insects, including egg and larval life stages, useful for automated high throughput bioassays.

Methods and systems for sorting and imaging insects

The present embodiments of the invention generally relate to methods for sorting and imaging insects, including egg and larval life stages, useful for automated high throughput bioassays.

Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.

PHI-4 polypeptides and methods for their use

Compositions and methods comprising polynucleotides and polypeptides having EPSP (5-enolpyruvylshikimate-3-phosphate) synthase (EPSPS) activity are provided. In specific embodiments, the sequence has an improved property, such as, but not limited to, improved catalytic capacity in the presence of the inhibitor, glyphosate. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the EPSPS sequences. Various methods of employing the EPSPS sequences are provided. Such methods include methods for producing a glyphosate tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein.

Plant EPSP synthases and methods of use

Compositions and methods comprising polynucleotides and polypeptides having 4-hydroxyphenylpyruvate dioxygenase (HPPD) activity and having insensitivity to an HPPD inhibitor are provided. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the HPPD sequences. Various methods of employing the HPPD sequences are provided. Such methods include, for example, methods for producing an HPPD inhibitor tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein. Methods are also provided to identify additional HPPD variants. Further provided are various methods and compositions that allow the various HPPD polypeptides and variant and fragments thereof to be expressed in a chloroplast or transported to a chloroplast.

Compositions and methods comprising sequences having hydroxyphenylpyruvate dioxygenase (HPPD) activity

Insecticidal proteins and methods for their use

Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.

Methods, systems, and software for identifying functional bio-molecules

Growing community of inventors

Menlo Park, CA, United States of America

Phillip A Patten