Amylin Pharmaceuticals, Inc.

Astrazeneca Pharmaceuticals LP

Cryocor, Inc.

Phillip A Estepa

David J Lentz

Philip Simpson

David G Matsuura

Tyler John Holschlag

Reynaldo B Halili, Jr

Victor Wei-Chung Chang

Pen injection devices () and methods of using a pen injection device are disclosed. Pen injection devices include a sterile dual transfer spike assembly () including a dual transfer spike defining a fluidic pathway; a first cartridge assembly () including a first cartridge () containing a first substance; a second cartridge assembly () including a second cartridge () containing a second substance; a plunger rod () translatable in a first direction; and a biasing mechanism () configured to bias the plunger rod in a second direction opposite the first direction. Methods of using a pen injection device having a first container, a second container, a plunger rod, and a biasing mechanism include activating the pen injection device, thereby creating a fluidic pathway between the first container and the second container; and translating the plunger rod at least once, thereby transferring a first substance from one container to the other container to mix with a second substance.

Pen injection device and method of using same

A device for steering a cardiac cryoablation catheter through the vasculature of a patient includes separate first and second deflection members that connect a tip member to the distal end of a catheter tube. Importantly, the first deflection member has a first flexural modulus, and the second deflection member has a second flexural modulus that is greater than the first flexural modulus. Also included is a control wire for pulling the tip member toward the catheter tube. In response, the first and second deflection members differentially deflect, according to their respective flexural moduli, to move the tip member for steering the catheter through the vasculature.

Wire reinforced articulation segment

Growing community of inventors

San Diego, CA, United States of America

Phillip A Estepa